Fig. 1From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in miceBilateral mechanical pain hypersensitivity during 5 weeks following dIoN-CCI surgery in mice. a-b At 0.008 g stimulus intensity, mechanical pain hypersensitivity in dIoN-CCI mice was observed in the ipsilateral (a) and contralateral side (b) to dIoN-CCI surgery compared with that of sham mice. c-d At 0.02 g stimulus intensity, mechanical pain hypersensitivity in dIoN-CCI mice was observed in the ipsilateral (c) and contralateral side (d) to dIoN-CCI surgery compared with that of sham mice. Data was expressed as Mean ± SEM. (n = 8 each group; *** P < 0.001 compared with the sham group, two-way ANOVA with post-hoc Bonferroni test). dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BL, baselineBack to article page