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Table 2 Plasma concentrations of Trp metabolites in healthy controls and migraineurs in both interictal and ictal periods

From: Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period

Metab. (nM)

Groups: Median ± IQR

p-values between groups

0. Healthy Control

1. Interictal Migraine

2. Ictal Migraine

Trp

53,203.65 ± 14,599.34

45,657.54 ± 4711.21

45,210.69 ± 11,292.49

0–1: 0.008

KYN

2505.77 ± 902.53

2119.41 ± 648.54

2418.99 ± 819.22

0–1: 0.003

KYNA

39.59 ± 15.32

33.56 ± 15.64

36.01 ± 10.57

0–1: 0.061

ANA

47.12 ± 27.79

35.23 ± 18.88

44.39 ± 28.61

0–1: 0.017

3-HK

47.29 ± 27.89

44.79 ± 18.73

48.41 ± 34.54

0–1: 0.511

XA

17.42 ± 13.46

11.39 ± 5.31

17.61 ± 14.66

0–1: 0.02

3-HANA

47.78 ± 24.59

44.85 ± 23.61

42.40 ± 21.24

0–1: 0.733

PICA

46.61 ± 25.63

34.86 ± 13.73

46.04 ± 24.39

0–1: 0.005

1–2: 0.049

QUINA

252.92 ± 169.69

190.86 ± 97.12

239.66 ± 178.05

0–1: 0.096

5-HT

468.11 ± 710.24

772.24 ± 493.89

491.23 ± 509.87

0–1: 0.243

5-HIAA

45.31 ± 20.46

37.46 ± 11.19

42.67 ± 11.10

0–1: 0.063

MELA

0.19 ± 0.11

0.16 ± 0.09

0.21 ± 0.10

0–1: 0.053

  1. All p-values were added in the table between control and interictal group of migraine patients. Significant difference between phases of migraine was revealed only in case of PICA
  2. IQR: interquartile range, Metab.: metabolites, Trp: Tryptophan, KYN: L-kynurenine, KYNA: Kynurenic acid, ANA: Anthranilic acid, 3-HK: 3-hydroxikynurenine, XA: Xanthurenic acid, 3-HANA: 3-hydroxi-anthranilic acid, PICA: Picolinic acid, QUINA: Quinolinic acid, 5-HT: 5-hydroxytryptamine, 5-HIAA: 5-hydroxi-indoleaceticacid, MELA: Melatonin
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The Journal of Headache and Pain

ISSN: 1129-2377

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