Fig. 4

Three centrality measures visualized for migraineurs and controls. These have been calculated from the PDNs in Fig. 2. Betweenness: how well a comorbidity connects other comorbidities; Closeness: how close the comorbidity is to other comorbidities in the PDN; Strength: the sum of phi correlations over all connected comorbidities. Note that instead of the raw centrality measure values, the standardized values (i.e. Z-scores) have been plotted. This enables the comparison of the values from the two PDNs. Generally, the centrality of the comorbidites in migraineurs follows the same pattern as in controls, however, there appears to be some differences in betweenness in F-codes, M75, N95 & R-codes