Fig. 2
Group differences of BOLDSV in the frequency band slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), and slow-3 (0.073–0.198 Hz). a Brain regions displaying increased BOLDSV in MIG patients compared with HCs. Separate voxel-wise permutation tests in each frequency band were performed for the SpV mask. Significant clusters (yellow) were identified using a threshold-free cluster enhancement (p < 0.05, FWE-corrected) (bottom). b Brain regions displaying decreased BOLDSV in MIG patients compared with HCs. All statistical images are displayed with significant clusters (voxel-level threshold p < 0.001 and cluster-level extent threshold p < 0.05, FWE-corrected). Bar graphs were expressed as mean ± standard error of the mean. Mean BOLDSV (Z) was extracted from a 3-mm sphere around the peak voxel of each significant cluster. Gray squares/bars represent MIG patients (n = 20), white squares/bars represent HC subjects (n = 26). MIG patients were divided into EM (n = 13) or CM (n = 7) groups for further subgroup comparison. ‡p < 0.05 (FWE-corrected). *p < 0.05, **p < 0.01, and ***p < 0.001 for unpaired t-test. S1, primary somatosensory cortex; AG, angular gyrus; MIG, migraine; HC, healthy control; EM, episodic migraine; CM, chronic migraine