Fig. 4

Interaction between migraine and restless legs syndrome. Available evidence suggests the existence of a bidirectional association between migraine and restless leg syndrome (RLS). RLS in patients with migraine seems to be associated with higher migraine frequency and related disability. It would be reasonable to systematically check patients with migraine for symptoms of RLS and adopt specific RLS treatments if needed; this approach should be considered complementary to that of migraine and may lead an improvement of migraine frequency and related disability. In the decision-making process for the choice of migraine preventive treatment clinicians should consider the possible exacerbating effect of antidepressants on RLS symptoms, and their effectiveness should be balance over the possible worsening effect on RLS