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Table 4 Comparison of biochemical variables between EM and CM-MO patients after detoxification

From: Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

  EM CM-MO at T1 Kruskal-Wallis test Post-hoc
All patients Responders Non-responders Responders vs. EM Responders vs. non-responders Non-responders vs. EM
n 27 28 23 5  
CGRP (pg/ml) 220.4 ± 84.4 275.2 ± 251.8 251.8 ± 383.2 383.2 ± 208.7 0.472
miR-382-5p (RQ) 3.3 ± 0.63 2.2 ± 0.4 1.7 ± 0.3 4.4 ± 1.1 0.006 0.042 0.034 1.000
miR-34a-5p (RQ) 18.4 ± 4.7 21.6 ± 4.0 20.7 ± 4.4 25.9 ± 10.4 0.248
  1. Legend: EM episodic migraine, CM-MO chronic migraine with medication overuse. Responders: patients with a reduction of at least 30% in monthly migraine days after detoxification. CGRP values are presented as mean ± standard deviation. microRNAs values are presented as mean ± standard error of the mean. RQ Relative quantification: 2−∆∆Ct = 2 − (∆Ct gene − ∆Ct housekeeping gene), Ct cycle threshold as defined in methods section. Statistical analysis: differences among EM groups, responders, and non-responders patients were analyzed with Kruskal-Wallis test followed by a post-hoc analysis; the levels of significance were further corrected with a Bonferroni method to account for multiple comparison