| T0 | T1 | Statistical analysis |
---|
All patients | Responders | Non-responders | All patients | Responders | Non-responders | TIME | GROUP | TIME x GROUP |
---|
n | 28 | 23 | 5 | 28 | 23 | 5 | – |
CGRP (pg/ml) | 393.3 ± 242.9 | 322.9 ± 164.1 | 717.1 ± 301.1 | 275.2 ± 251.8 | 251.8 ± 383.2 | 383.2 ± 208.7 | 0.001 | 0.033 | 0.542 |
miR-382-5p (RQ) | 14.6 ± 3.2 | 10.4 ± 1.1 | 33.9 ± 15.6 | 2.2 ± 0.4 | 1.7 ± 0.3 | 4.4 ± 1.1 | 0.001 | 0.009 | 0.344 |
miR-34a-5p (RQ) | 69.5 ± 8.5 | 66.7 ± 8.8 | 81.8 ± 27.2 | 21.6 ± 4.0 | 20.7 ± 4.4 | 25.9 ± 10.4 | 0.001 | 0.775 | 0.804 |
- Legend: CM-MO chronic migraine with medication overuse. Responders: patients with a reduction of at least 30% of monthly migraine days after detoxification. T0: baseline evaluation; T1: 2 months after discharge from in-hospital detoxification. CGRP values are presented as mean ± standard deviation. microRNAs values are presented as “mean ± standard error of the mean”. RQ Relative quantification: 2−∆∆Ct = 2 − (∆Ct gene − ∆Ct housekeeping gene), Ct cycle threshold as defined in methods section. Statistical analysis: non-parametric tests for repeated measures with two factors: factor TIME (T0 vs. T1), and factor GROUP (responders vs. non-responders)