Skip to main content

Table 3 Biochemical data of CM-MO patients before and after detoxification

From: Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

  T0 T1 Statistical analysis
All patients Responders Non-responders All patients Responders Non-responders TIME GROUP TIME
x
GROUP
n 28 23 5 28 23 5
CGRP (pg/ml) 393.3 ± 242.9 322.9 ± 164.1 717.1 ± 301.1 275.2 ± 251.8 251.8 ± 383.2 383.2 ± 208.7 0.001 0.033 0.542
miR-382-5p (RQ) 14.6 ± 3.2 10.4 ± 1.1 33.9 ± 15.6 2.2 ± 0.4 1.7 ± 0.3 4.4 ± 1.1 0.001 0.009 0.344
miR-34a-5p (RQ) 69.5 ± 8.5 66.7 ± 8.8 81.8 ± 27.2 21.6 ± 4.0 20.7 ± 4.4 25.9 ± 10.4 0.001 0.775 0.804
  1. Legend: CM-MO chronic migraine with medication overuse. Responders: patients with a reduction of at least 30% of monthly migraine days after detoxification. T0: baseline evaluation; T1: 2 months after discharge from in-hospital detoxification. CGRP values are presented as mean ± standard deviation. microRNAs values are presented as “mean ± standard error of the mean”. RQ Relative quantification: 2−∆∆Ct = 2 − (∆Ct gene − ∆Ct housekeeping gene), Ct cycle threshold as defined in methods section. Statistical analysis: non-parametric tests for repeated measures with two factors: factor TIME (T0 vs. T1), and factor GROUP (responders vs. non-responders)