| Migraine Characteristics | Patient Function and Disability | |||||||
---|---|---|---|---|---|---|---|---|---|
 | Years since diagnosis | Monthly migraine headache days | Monthly migraine headache days with acute medication |  | MSQ-RFR score | PGI-S score | MIDAS total score | ||
Age group (years) | Treat. | N | Mean (SD) | Mean (SD) | Mean (SD) | N | Mean (SD) | Mean (SD) | Mean (SD) |
Episodic | |||||||||
≤40 | PBO 120 240 | 381 219 220 | 14.0 (7.6) 14.2 (8.5) 14.3 (7.7) | 9.3 (2.9) 9.3 (3.0) 9.2 (2.9) | 6.9 (3.5) 7.1 (3.6) 7.1 (3.4) | 379 219 218 | 52.1 (15.9) 51.8 (15.4) 48.9 (17.1)2 | 4.2 (1.1)1 4.2 (1.1) 4.3 (1.2) | 33.1 (26.4) 29.9 (23.5) 37.9 (28.1)2 |
> 40 to ≤ 50 | PBO 120 240 | 298 125 113 | 22.0 (11.5) 23.1 (10.4) 22.4 (11.8) | 9.3 (3.1) 8.9 (2.7) 9.0 (2.9) | 8.2 (3.3) 7.7 (3.1) 7.8 (3.0) | 296 124 111 | 51.6 (14.4) 51.6 (15.7) 51.5 (15.7) | 4.3 (1.2) 4.4 (1.1) 4.4 (1.2) | 34.0 (31.4) 35.6 (31.0) 30.4 (24.6) |
> 50 to ≤ 55 | PBO 120 240 | 96 54 58 | 25.3 (12.8) 27.8 (12.2) 26.4 (13.1) | 8.7 (3.0) 9.1 (2.9) 9.1 (3.2) | 7.7 (3.5) 8.1 (3.3) 8.0 (3.3) | 96 54 58 | 51.7 (17.1) 50.8 (16.3) 50.3 (17.3) | 4.3 (1.3) 4.2 (1.4) 4.4 (1.2) | 32.0 (23.1) 36.3 (38.7) 31.8 (33.7) |
> 55 to ≤ 65 | PBO 120 240 | 119 46 44 | 34.1 (14.0) 34.8 (13.9) 30.5 (14.6) | 8.7 (3.0) 8.9 (3.4) 8.8 (3.0) | 7.7 (3.2) 7.5 (3.9) 7.3 (3.3) | 116 46 43 | 54.0 (16.3) 55.3 (13.8) 54.2 (15.2) | 4.2 (1.2) 4.0 (1.1) 4.3 (1.1) | 31.7 (36.6) 26.0 (23.3) 30.3 (29.2) |
p-value3 |  | < 0.001 | 0.128 | < 0.001 |  | 0.075 | 0.349 | 0.468 | |
Chronic | |||||||||
≤40 | PBO 120 240 | 253 144 127 | 14.8 (8.2) 14.7 (8.8) 13.3 (8.2) | 20.0 (4.6) 19.7 (4.2) 19.6 (4.6) | 14.3 (7.1) 13.9 (6.5) 13.3 (6.2) | 247 141 125 | 37.8 (16.7) 37.6 (17.0) 39.1 (17.1) | 4.8 (1.3) 4.9 (1.2) 4.7 (1.2) | 69.1 (53.6) 64.2 (51.7) 76.4 (66.6) |
> 40 to ≤ 50 | PBO 120 240 | 162 75 76 | 24.1 (11.3) 23.6 (11.9) 21.9 (12.1) | 19.4 (4.5) 19.1 (4.3) 19.1 (4.6) | 16.7 (5.7) 16.0 (5.8) 15.2 (6.3) | 159 75 74 | 37.7 (18.3) 41.0 (18.1) 37.5 (18.3) | 5.1 (1.2) 4.8 (1.3) 5.0 (1.5) | 76.3 (67.7) 59.3 (45.9)2 65.4 (60.8) |
> 50 to ≤ 55 | PBO 120 240 | 65 31 32 | 28.7 (13.5) 25.8 (14.5) 24.1 (11.9) | 18.9 (3.9) 18.3 (4.7) 17.4 (4.3) | 15.8 (5.6) 16.0 (6.7) 13.4 (5.6) | 63 29 32 | 38.6 (16.7) 40.9 (17.8) 38.7 (13.9) | 4.9 (1.2) 4.6 (1.2) 4.9 (1.2) | 63.0 (49.5) 63.3 (51.1) 60.5 (48.9) |
> 55 to ≤ 65 | PBO 120 240 | 78 28 42 | 35.0 (12.9) 34.9 (13.6) 34.3 (11.7) | 19.0 (5.2) 19.4 (4.4) 19.4 (4.6) | 16.8 (6.5) 18.1 (4.0) 17.6 (5.7) | 77 27 41 | 41.5 (16.7) 41.6 (16.4) 41.2 (18.9) | 4.8 (1.3) 4.6 (1.5) 5.2 (1.4) | 56.0 (49.7) 61.4 (47.5) 60.8 (71.8) |
p-value3 |  | < 0.001 | 0.006 | < 0.001 |  | 0.214 | 0.181 | 0.128 |