Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging

Table 2 Fractional anisotropy, mean diffusion, axial diffusion and radial diffusion values of the trigeminal nerve root entry zone in control and migraine subjects. Total nerve as well as caudal, middle and rostral third values are shown. * p < 0.05, significant within group difference between left and right nerve volumes. # p < 0.05, significant between group difference between left and right nerve volumes

	Controls		Migraineurs
	(n = 38)		(n = 38)
	Left	Right	Left	Right
Fractional anisotropy (mean [±SEM])
Total nerve	.26 (.01)#	.25 (.01)	.23 (.01)	.24 (.01)
Caudal third	.24 (.01)	.24 (.01)	.22 (.01)	.23 (.01)
Middle third	.28 (.01)#	.27 (.01)	.25 (.01)	.26 (.01)
Rostral third	.25 (.01)*#	.24 (.01)	.22 (.01)	.22 (.01)
Mean diffusion (mean [±SEM] × 10^− 3 mm²/sec)
Total nerve	2.52 (.04)	2.51 (.05)	2.61 (.04)	2.54 (.04)
Caudal third	2.64 (.06)	2.62 (.06)	2.66 (.06)	2.67 (.06)
Middle third	2.44 (.04)	2.43 (.05)	2.53 (.05)	2.50 (.05)
Rostral third	2.59 (.05)	2.50 (.07)	2.70 (.05)	2.62 (.05)
Axial diffusion (mean [±SEM] × 10⁻³ mm²/sec)
Total nerve	3.22 (.05)	3.17 (.06)	3.23 (.05)*	3.14 (.04)
Caudal third	3.26 (.07)	3.27 (.07)	3.25 (.07)	3.22 (.06)
Middle third	3.14 (.05)	3.12 (.06)	3.18 (.06)	3.11 (.05)
Rostral third	3.24 (.06)	3.13 (.08)	3.29 (.06)*	3.14 (.05)
Radial diffusion (mean [±SEM] × 10⁻³ mm²/sec)
Total nerve	2.21 (.04)	2.19 (.05)	2.30 (.04)	2.23 (.04)
Caudal third	2.34 (.06)	2.34 (.06)	2.38 (.06)	2.35 (.06)
Middle third	2.09 (.04)#	2.09 (.05)	2.22 (.05)	2.14 (.05)
Rostral third	2.27 (.05)#	2.20 (.06)	2.42 (.05)*	2.27 (.05)

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