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Table 4 Factor associated with persistent use of pregabalin at one year

From: Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study

 UnivariateMultivariable
VariableOdds Ratio (95% CI)p ValueOdds Ratio (95% CI)p Value
Male1.24 (1.19–1.28)<.0011.14 (1.09–1.18)< 0.001
Age, per year1 (1–1)0.0011.01 (1.01–1.01)< 0.001
Monthly income NT$
NT 0–21,0091 1 
NT 210,10-36,8250.87 (0.84–0.91)< 0.0010.97 (0.93–1.01)0.187
> 36,8250.75 (0.71–0.79)< 0.0010.87 (0.83–0.92)< 0.001
Region of Taiwan
Northern region1 1 
Central region0.94 (0.9–0.98)0.0070.86 (0.82–0.9)< 0.001
Southern region0.92 (0.83–1.02)0.1260.79 (0.71–0.89)< 0.001
Eastern region0.9 (0.86–0.94)< 0.0011 (0.95–1.05)0.981
Charlson Comorbidity Index score, per 1 score1.06 (1.05–1.06)< 0.001  
Specialty of prescribing physicians
Neurology1 1 
Anesthesiology0.99 (0.91–1.07)0.7151.08 (0.99–1.17)0.094
Physiatry0.73 (0.65–0.82)< 0.0010.92 (0.82–1.03)0.141
Psychiatry1.28 (1–1.64)0.0471.31 (1.01–1.7)0.039
Rheumatology1.14 (1.08–1.21)< 0.0011.64 (1.54–1.76)< 0.001
Others0.41 (0.39–0.43)< 0.0010.61 (0.58–0.64)< 0.001
Indications
Herpes zoster1 1 
Diabetic peripheral neuropathic pain4.24 (4–4.51)< 0.0013.05 (2.85–3.27)< 0.001
Fibromyalgia2.04 (1.92–2.17)< 0.0011.59 (1.48–1.7)< 0.001
Epilepsy11.31 (10.43–12.28)< 0.0018.04 (7.33–8.81)< 0.001
Other musculoskeletal diseases1.88 (1.77–1.99)< 0.0011.64 (1.54–1.75)< 0.001
Others2.37 (2.23–2.52)< 0.0011.98 (1.85–2.11)< 0.001
Concomitant medications
Gabapentin2.04 (1.95–2.14)< 0.0012.04 (1.94–2.15)< 0.001
Duloxetine2.17 (2.02–2.33)< 0.0011.53 (1.42–1.65)< 0.001
NSAIDs0.56 (0.54–0.58)< 0.0010.72 (0.7–0.75)< 0.001
Acetaminophen0.61 (0.59–0.64)< 0.0010.79 (0.76–0.83)< 0.001
Tramadol1.43 (1.32–1.54)< 0.0011.3 (1.2–1.42)< 0.001
Acetaminophen/tramadol0.99 (0.95–1.03)0.6201.08 (1.03–1.12)0.001
Lidocaine medicated plaster1.2 (1.01–1.42)0.0351.37 (1.15–1.64)0.001
Anti-viral agents0.22 (0.19–0.25)< 0.0010.41 (0.35–0.47)< 0.001
Daily dosage, per 75 mg1.16 (1.13–1.19)< 0.0011.12 (1.10–1.15)< 0.001
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