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Table 4 Factor associated with persistent use of pregabalin at one year

From: Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study

 

Univariate

Multivariable

Variable

Odds Ratio (95% CI)

p Value

Odds Ratio (95% CI)

p Value

Male

1.24 (1.19–1.28)

<.001

1.14 (1.09–1.18)

< 0.001

Age, per year

1 (1–1)

0.001

1.01 (1.01–1.01)

< 0.001

Monthly income NT$

NT 0–21,009

1

 

1

 

NT 210,10-36,825

0.87 (0.84–0.91)

< 0.001

0.97 (0.93–1.01)

0.187

> 36,825

0.75 (0.71–0.79)

< 0.001

0.87 (0.83–0.92)

< 0.001

Region of Taiwan

Northern region

1

 

1

 

Central region

0.94 (0.9–0.98)

0.007

0.86 (0.82–0.9)

< 0.001

Southern region

0.92 (0.83–1.02)

0.126

0.79 (0.71–0.89)

< 0.001

Eastern region

0.9 (0.86–0.94)

< 0.001

1 (0.95–1.05)

0.981

Charlson Comorbidity Index score, per 1 score

1.06 (1.05–1.06)

< 0.001

  

Specialty of prescribing physicians

Neurology

1

 

1

 

Anesthesiology

0.99 (0.91–1.07)

0.715

1.08 (0.99–1.17)

0.094

Physiatry

0.73 (0.65–0.82)

< 0.001

0.92 (0.82–1.03)

0.141

Psychiatry

1.28 (1–1.64)

0.047

1.31 (1.01–1.7)

0.039

Rheumatology

1.14 (1.08–1.21)

< 0.001

1.64 (1.54–1.76)

< 0.001

Others

0.41 (0.39–0.43)

< 0.001

0.61 (0.58–0.64)

< 0.001

Indications

Herpes zoster

1

 

1

 

Diabetic peripheral neuropathic pain

4.24 (4–4.51)

< 0.001

3.05 (2.85–3.27)

< 0.001

Fibromyalgia

2.04 (1.92–2.17)

< 0.001

1.59 (1.48–1.7)

< 0.001

Epilepsy

11.31 (10.43–12.28)

< 0.001

8.04 (7.33–8.81)

< 0.001

Other musculoskeletal diseases

1.88 (1.77–1.99)

< 0.001

1.64 (1.54–1.75)

< 0.001

Others

2.37 (2.23–2.52)

< 0.001

1.98 (1.85–2.11)

< 0.001

Concomitant medications

Gabapentin

2.04 (1.95–2.14)

< 0.001

2.04 (1.94–2.15)

< 0.001

Duloxetine

2.17 (2.02–2.33)

< 0.001

1.53 (1.42–1.65)

< 0.001

NSAIDs

0.56 (0.54–0.58)

< 0.001

0.72 (0.7–0.75)

< 0.001

Acetaminophen

0.61 (0.59–0.64)

< 0.001

0.79 (0.76–0.83)

< 0.001

Tramadol

1.43 (1.32–1.54)

< 0.001

1.3 (1.2–1.42)

< 0.001

Acetaminophen/tramadol

0.99 (0.95–1.03)

0.620

1.08 (1.03–1.12)

0.001

Lidocaine medicated plaster

1.2 (1.01–1.42)

0.035

1.37 (1.15–1.64)

0.001

Anti-viral agents

0.22 (0.19–0.25)

< 0.001

0.41 (0.35–0.47)

< 0.001

Daily dosage, per 75 mg

1.16 (1.13–1.19)

< 0.001

1.12 (1.10–1.15)

< 0.001