From: Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study
 | Univariate | Multivariable | ||
---|---|---|---|---|
Variable | Odds Ratio (95% CI) | p Value | Odds Ratio (95% CI) | p Value |
Male | 1.24 (1.19–1.28) | <.001 | 1.14 (1.09–1.18) | < 0.001 |
Age, per year | 1 (1–1) | 0.001 | 1.01 (1.01–1.01) | < 0.001 |
Monthly income NT$ | ||||
NT 0–21,009 | 1 |  | 1 |  |
NT 210,10-36,825 | 0.87 (0.84–0.91) | < 0.001 | 0.97 (0.93–1.01) | 0.187 |
> 36,825 | 0.75 (0.71–0.79) | < 0.001 | 0.87 (0.83–0.92) | < 0.001 |
Region of Taiwan | ||||
Northern region | 1 | Â | 1 | Â |
Central region | 0.94 (0.9–0.98) | 0.007 | 0.86 (0.82–0.9) | < 0.001 |
Southern region | 0.92 (0.83–1.02) | 0.126 | 0.79 (0.71–0.89) | < 0.001 |
Eastern region | 0.9 (0.86–0.94) | < 0.001 | 1 (0.95–1.05) | 0.981 |
Charlson Comorbidity Index score, per 1 score | 1.06 (1.05–1.06) | < 0.001 |  |  |
Specialty of prescribing physicians | ||||
Neurology | 1 | Â | 1 | Â |
Anesthesiology | 0.99 (0.91–1.07) | 0.715 | 1.08 (0.99–1.17) | 0.094 |
Physiatry | 0.73 (0.65–0.82) | < 0.001 | 0.92 (0.82–1.03) | 0.141 |
Psychiatry | 1.28 (1–1.64) | 0.047 | 1.31 (1.01–1.7) | 0.039 |
Rheumatology | 1.14 (1.08–1.21) | < 0.001 | 1.64 (1.54–1.76) | < 0.001 |
Others | 0.41 (0.39–0.43) | < 0.001 | 0.61 (0.58–0.64) | < 0.001 |
Indications | ||||
Herpes zoster | 1 | Â | 1 | Â |
Diabetic peripheral neuropathic pain | 4.24 (4–4.51) | < 0.001 | 3.05 (2.85–3.27) | < 0.001 |
Fibromyalgia | 2.04 (1.92–2.17) | < 0.001 | 1.59 (1.48–1.7) | < 0.001 |
Epilepsy | 11.31 (10.43–12.28) | < 0.001 | 8.04 (7.33–8.81) | < 0.001 |
Other musculoskeletal diseases | 1.88 (1.77–1.99) | < 0.001 | 1.64 (1.54–1.75) | < 0.001 |
Others | 2.37 (2.23–2.52) | < 0.001 | 1.98 (1.85–2.11) | < 0.001 |
Concomitant medications | ||||
Gabapentin | 2.04 (1.95–2.14) | < 0.001 | 2.04 (1.94–2.15) | < 0.001 |
Duloxetine | 2.17 (2.02–2.33) | < 0.001 | 1.53 (1.42–1.65) | < 0.001 |
NSAIDs | 0.56 (0.54–0.58) | < 0.001 | 0.72 (0.7–0.75) | < 0.001 |
Acetaminophen | 0.61 (0.59–0.64) | < 0.001 | 0.79 (0.76–0.83) | < 0.001 |
Tramadol | 1.43 (1.32–1.54) | < 0.001 | 1.3 (1.2–1.42) | < 0.001 |
Acetaminophen/tramadol | 0.99 (0.95–1.03) | 0.620 | 1.08 (1.03–1.12) | 0.001 |
Lidocaine medicated plaster | 1.2 (1.01–1.42) | 0.035 | 1.37 (1.15–1.64) | 0.001 |
Anti-viral agents | 0.22 (0.19–0.25) | < 0.001 | 0.41 (0.35–0.47) | < 0.001 |
Daily dosage, per 75 mg | 1.16 (1.13–1.19) | < 0.001 | 1.12 (1.10–1.15) | < 0.001 |