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Table 4 Observed case analysis of patients free of disability at specified times post-dose for selected attacks

From: Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

 Time pointLasmiditan 100 mga
n/N (%)
Lasmiditan 200 mga
n/N (%)
Overalla
n/N (%)
Attack 1Baseline16/931 (1.7)26/963 (2.7)42/1894 (2.2)
0.5 h60/797 (7.5)53/828 (6.4)113/1625 (7.0)
1 h176/814 (21.6)183/846 (21.6)359/1660 (21.6)
2 h327/847 (38.6)341/869 (39.2)668/1716 (38.9)
4 h385/585 (65.8)429/677 (63.4)814/1262 (64.5)
24 h374/432 (86.6)420/495 (84.8)794/927 (85.7)
48 h365/414 (88.2)436/504 (86.5)801/918 (87.3)
Attack 5Baseline5/560 (0.9)5/566 (0.9)10/1126 (0.9)
0.5 h28/477 (5.9)21/491 (4.3)49/968 (5.1)
1 h80/484 (16.5)89/510 (17.5)169/994 (17.0)
2 h189/505 (37.4)194/504 (38.5)383/1009 (38.0)
4 h233/345 (67.5)249/372 (66.9)482/717 (67.2)
24 h232/271 (85.6)249/299 (83.3)481/570 (84.4)
48 h243/271 (89.7)239/286 (83.6)482/557 (86.5)
Attack 10Baseline2/324 (0.6)4/298 (1.3)6/622 (1.0)
0.5 h11/275 (4.0)14/262 (5.3)25/537 (4.7)
1 h41/281 (14.6)48/263 (18.3)89/544 (16.4)
2 h85/285 (29.8)98/269 (36.4)183/554 (33.0)
4 h109/172 (63.4)133/192 (69.3)242/364 (66.5)
24 h100/130 (76.9)116/140 (82.9)216/270 (80.0)
48 h108/121 (89.3)116/138 (84.1)224/259 (86.5)
Attack 15Baseline1/193 (0.5)0/174 (0)1/367 (0.3)
0.5 h6/154 (3.9)6/145 (4.1)12/299 (4.0)
1 h15/157 (9.6)25/146 (17.1)40/303 (13.2)
2 h43/172 (25.0)57/156 (36.5)100/328 (30.5)
4 h54/97 (55.7)65/104 (62.5)119/201 (59.2)
24 h57/69 (82.6)81/90 (90.0)138/159 (86.8)
48 h63/76 (82.9)71/85 (83.5)134/161 (83.2)
Attack 20Baseline2/116 (1.7)0/108 (0)2/224 (0.9)
0.5 h1/98 (1.0)4/95 (4.2)5/193 (2.6)
1 h12/104 (11.5)17/92 (18.5)29/196 (14.8)
2 h25/103 (24.3)36/94 (38.3)61/197 (31.0)
4 h28/52 (53.8)40/59 (67.8)68/111 (61.3)
24 h33/44 (75.0)41/51 (80.4)74/95 (77.9)
48 h35/42 (83.3)43/52 (82.7)78/94 (83.0)
  1. Abbreviations: n = number of patients in category; N = number of patients with data available
  2. Based on electronic diary question “How much is your migraine interfering with your normal activities.” Response options were “not at all,” “mild interference,” “marked interference,” and “need complete bed rest”. Data shown for “not at all” (no disability). Analysis of “interference with normal activities” during the course of each attack included all patients who took study medication and reported interference values at each time point
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