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Table 4 Subgroup analysis of genetic variants with statistically significance (P-value< 0.05) from observational studies based on ethnicity

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, yearGene/variantComparisonOR (95%CI)P-ValueEthnicityNo. of cases/controlsFPRP Values at Prior probabilityBFDP 0.05BFDP 0.001
OR 1.2OR 1.5
0.050.0010.050.001
Liu L, 2019 [48]MTHFR/rs1801133T vs. C1.18 (1.04–1.34)0.012Caucasian 209635/275920.2530.9470.1690.9150.7660.994
Liu L, 2019 [48]MTHFR/rs1801133TT vs. CT + CC1.25 (1.02–1.53)0.035Caucasian 209635/275920.6260.9890.3760.9690.8670.997
Liu L, 2019 [48]MTHFR/rs1801133TT vs. CC1.28 (1.02–1.60)0.036Caucasian 209635/275920.6670.9910.3840.9680.8860.997
Dong H, 2018 [46]eNOS/rs2070744CC vs. TC + TT1.62 (1.03–2.56)0.04Caucasian 4435/3440.8810.9970.6650.9910.9080.998
Terrazzino S, 2017 [44]BDNF/rs6265A vs. G1.17 (1.03–1.34)0.014Caucasian 52884/37600.4080.9730.3070.9590.8560.997
Terrazzino S, 2017 [44]BDNF/rs6265AA + GA vs. GG1.22 (1.05–1.41)0.011Caucasian 52884/37600.2470.9450.1190.8770.6940.992
Cai X, 2017 [42]BDNF/rs2049046A vs. T0.88 (0.79–0.98)0.02Caucasian 41260/13800.3110.9600.2750.9520.8550.997
Cai X, 2017 [42]BDNF/rs2049046AA vs. TA + TT0.80 (0.67–0.96)0.02Caucasian 41260/13800.4860.9800.2430.9440.8090.996
Cai X, 2017 [42]BDNF/rs2049046AA vs. TT0.78 (0.62–0.97)0.02Caucasian 41260/13800.6370.9890.3450.9650.8530.997
Cai X, 2017 [42]BDNF/rs2049046AA vs. TA0.81 (0.67–0.99)0.03Caucasian 41260/13800.6580.9900.4360.9760.8870.976
Li L, 2015 [37]ESR1/rs1801132GG vs. CC1.63 (1.20–2.22)0.002Caucasian 41693/17190.5860.9870.1100.8660.6000.988
Li L, 2015 [37]ESR1/rs1801132GG vs. CG + CC1.63 (1.21–2.21)0.001Caucasian 41693/17190.5640.9860.0960.8480.5720.986
Li L, 2015 [37]ESR1/rs2228480AG vs. GG1.19 (1.04–1.35)0.009Caucasian 51959/18260.1920.9260.1160.8730.6960.992
Li L, 2015 [37]ESR1/rs2228480AA + AG vs. GG1.17 (1.04–1.33)0.016Caucasian 51959/18260.3230.9620.2370.9420.8210.996
Chen M, 2015 [35]TNF-α/rs1800629A vs. G1.74 (1.13–2.67)0.012Non-Caucasian 5985/9560.8280.9960.4620.9780.8510.997
Chen M, 2015 [35]TNF-α/rs1800629AA+GA vs. GG1.82 (1.15–2.87)0.010Non-Caucasian 5985/9560.8380.9960.4830.9800.8540.997
Chen M, 2015 [35]TNF-α/rs1800629GA vs. GG1.78 (1.17–2.72)0.007Non-Caucasian 5985/9560.8100.9960.4050.9730.8280.996
Chen M, 2015 [35]NOS3/rs1799983TT vs. GT + GG1.84 (1.02–3.33)0.043Non-Caucasian 3504/3390.9140.9980.7700.9940.9230.998
Chen M, 2015 [35]NOS3/rs1799983TT vs. GG2.10 (1.14–3.88)0.018Non-Caucasian 3504/3390.9020.9980.7060.9920.9070.998
Liu R, 2014 [32]TNF-β/rs909253GG vs. AG + AA1.38 (1.04–1.84)0.027Non-Caucasian 3746/7170.7590.9940.4280.9750.8690.997
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