Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Zhao, Yating; Zhu, Ruixia; Xiao, Tongling; Liu, Xu

doi:10.1186/s10194-020-01087-5

The Journal of Headache and Pain

Table 4 Subgroup analysis of genetic variants with statistically significance (P-value< 0.05) from observational studies based on ethnicity

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, year	Gene/variant	Comparison	OR (95%CI)	P-Value	Ethnicity	No. of cases/controls	FPRP Values at Prior probability				BFDP 0.05	BFDP 0.001
							OR 1.2		OR 1.5
							0.05	0.001	0.05	0.001
Liu L, 2019 [48]	MTHFR/rs1801133	T vs. C	1.18 (1.04–1.34)	0.012	Caucasian 20	9635/27592	0.253	0.947	0.169	0.915	0.766	0.994
Liu L, 2019 [48]	MTHFR/rs1801133	TT vs. CT + CC	1.25 (1.02–1.53)	0.035	Caucasian 20	9635/27592	0.626	0.989	0.376	0.969	0.867	0.997
Liu L, 2019 [48]	MTHFR/rs1801133	TT vs. CC	1.28 (1.02–1.60)	0.036	Caucasian 20	9635/27592	0.667	0.991	0.384	0.968	0.886	0.997
Dong H, 2018 [46]	eNOS/rs2070744	CC vs. TC + TT	1.62 (1.03–2.56)	0.04	Caucasian 4	435/344	0.881	0.997	0.665	0.991	0.908	0.998
Terrazzino S, 2017 [44]	BDNF/rs6265	A vs. G	1.17 (1.03–1.34)	0.014	Caucasian 5	2884/3760	0.408	0.973	0.307	0.959	0.856	0.997
Terrazzino S, 2017 [44]	BDNF/rs6265	AA + GA vs. GG	1.22 (1.05–1.41)	0.011	Caucasian 5	2884/3760	0.247	0.945	0.119	0.877	0.694	0.992
Cai X, 2017 [42]	BDNF/rs2049046	A vs. T	0.88 (0.79–0.98)	0.02	Caucasian 4	1260/1380	0.311	0.960	0.275	0.952	0.855	0.997
Cai X, 2017 [42]	BDNF/rs2049046	AA vs. TA + TT	0.80 (0.67–0.96)	0.02	Caucasian 4	1260/1380	0.486	0.980	0.243	0.944	0.809	0.996
Cai X, 2017 [42]	BDNF/rs2049046	AA vs. TT	0.78 (0.62–0.97)	0.02	Caucasian 4	1260/1380	0.637	0.989	0.345	0.965	0.853	0.997
Cai X, 2017 [42]	BDNF/rs2049046	AA vs. TA	0.81 (0.67–0.99)	0.03	Caucasian 4	1260/1380	0.658	0.990	0.436	0.976	0.887	0.976
Li L, 2015 [37]	ESR1/rs1801132	GG vs. CC	1.63 (1.20–2.22)	0.002	Caucasian 4	1693/1719	0.586	0.987	0.110	0.866	0.600	0.988
Li L, 2015 [37]	ESR1/rs1801132	GG vs. CG + CC	1.63 (1.21–2.21)	0.001	Caucasian 4	1693/1719	0.564	0.986	0.096	0.848	0.572	0.986
Li L, 2015 [37]	ESR1/rs2228480	AG vs. GG	1.19 (1.04–1.35)	0.009	Caucasian 5	1959/1826	0.192	0.926	0.116	0.873	0.696	0.992
Li L, 2015 [37]	ESR1/rs2228480	AA + AG vs. GG	1.17 (1.04–1.33)	0.016	Caucasian 5	1959/1826	0.323	0.962	0.237	0.942	0.821	0.996
Chen M, 2015 [35]	TNF-α/rs1800629	A vs. G	1.74 (1.13–2.67)	0.012	Non-Caucasian 5	985/956	0.828	0.996	0.462	0.978	0.851	0.997
Chen M, 2015 [35]	TNF-α/rs1800629	AA+GA vs. GG	1.82 (1.15–2.87)	0.010	Non-Caucasian 5	985/956	0.838	0.996	0.483	0.980	0.854	0.997
Chen M, 2015 [35]	TNF-α/rs1800629	GA vs. GG	1.78 (1.17–2.72)	0.007	Non-Caucasian 5	985/956	0.810	0.996	0.405	0.973	0.828	0.996
Chen M, 2015 [35]	NOS3/rs1799983	TT vs. GT + GG	1.84 (1.02–3.33)	0.043	Non-Caucasian 3	504/339	0.914	0.998	0.770	0.994	0.923	0.998
Chen M, 2015 [35]	NOS3/rs1799983	TT vs. GG	2.10 (1.14–3.88)	0.018	Non-Caucasian 3	504/339	0.902	0.998	0.706	0.992	0.907	0.998
Liu R, 2014 [32]	TNF-β/rs909253	GG vs. AG + AA	1.38 (1.04–1.84)	0.027	Non-Caucasian 3	746/717	0.759	0.994	0.428	0.975	0.869	0.997

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