Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Zhao, Yating; Zhu, Ruixia; Xiao, Tongling; Liu, Xu

doi:10.1186/s10194-020-01087-5

The Journal of Headache and Pain

Table 3 Subgroup analysis of genetic variants with statistically significance (P-value< 0.05) from observational studies based on migraine subtype

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, year	Gene/variant	Comparison	OR (95%CI)	P-value	Subtypes	No. of cases/controls	FPRP Values at Prior probability				BFDP 0.05	BFDP 0.001
							OR 1.2		OR 1.5
							0.05	0.001	0.05	0.001
Liu L, 2019 [48]	MTHFR/rs1801133	T vs. C	1.28 (1.09–1.51)	0.003	MA	4313/28092	0.226	0.939	0.063	0.778	0.560	0.985
Liu L, 2019 [48]	MTHFR/rs1801133	CT + TT vs. CC	1.20 (1.00–1.44)	0.049	MA	4313/28092	0.655	0.990	0.489	0.981	0.904	0.998
Liu L, 2019 [48]	MTHFR/rs1801133	TT vs. CT + CC	1.46 (1.10–1.95)	0.010	MA	4313/28092	0.682	0.991	0.256	0.948	0.788	0.995
Liu L, 2019 [48]	MTHFR/rs1801133	TT vs. CC	1.51 (1.09–2.08)	0.012	MA	4313/28092	0.735	0.993	0.314	0.960	0.812	0.996
Terrazzino S, 2017 [44]	BDNF/rs6265	GA + AA vs. GG	1.22 (1.00–1.47)	0.047	MA	717/1593	0.617	0.988	0.413	0.974	0.882	0.997
Li L, 2015 [37]	ESR1/rs1801132	GG vs. CC	1.59 (1.17–2.15)	0.003	MA	1427/1919	0.593	0.987	0.123	0.880	0.632	0.989
Li L, 2015 [37]	ESR1/rs1801132	GG vs. CG + CC	1.58 (1.18–2.13)	0.002	MA	1427/1919	0.590	0.987	0.122	0.880	0.633	0.989
Chen M, 2015 [35]	TNF-α/rs1800629	AA+GA vs. GG	1.17 (1.05–1.30)	0.004	MA	1763/21837	0.089	0.837	0.062	0.777	0.582	0.987
Chen M, 2015 [35]	TNF-α/rs1800629	A vs. G	1.13 (1.03–1.24)	0.010	MA	1763/21837	0.173	0.917	0.159	0.908	0.783	0.995
Chen M, 2015 [35]	TNF-α/rs1800629	GA vs. GG	1.17 (1.05–1.31)	0.005	MA	1763/21837	0.115	0.906	0.110	0.866	0.694	0.992
Chen M, 2015 [35]	NOS3/rs1799983	TT vs. GG	1.61 (1.12–2.31)	0.010	MA	440/881	0.770	0.994	0.345	0.965	0.816	0.996
Chen M, 2015 [35]	NOS3/rs1799983	TT vs. GT + GG	1.50 (1.08–2.09)	0.016	MA	440/881	0.771	0.994	0.387	0.971	0.843	0.996
Liu H, 2011 [23]	5-HTT/VNTR	12/other	1.33 (1.01–1.75)	0.042	MA	176/629	0.774	0.994	0.496	0.981	0.891	0.998
Liu H, 2011 [23]	5-HTT/VNTR	12/12 vs. 12/other +other	1.58 (1.07–2.33)	0.021	MA	176/629	0.829	0.996	0.501	0.981	0.873	0.997
Schurks M, 2010 [20]	ACE/rs1799752	II vs. ID + DD	0.71 (0.55–0.93)	0.011	MA	1761/22310	0.667	0.991	0.266	0.950	0.801	0.995
Liu L, 2019 [48]	MTHFR/rs1801131	C vs. A	1.43 (1.06–1.92)	0.018	MO	159/1477	0.730	0.993	0.345	0.965	0.835	0.996
Liu L, 2019 [48]	MTHFR/rs1801131	CC vs. AC + AA	2.74 (1.46–5.14)	0.002	MO	159/1477	0.864	0.997	0.515	0.982	0.842	0.996
Liu L, 2019 [48]	MTHFR/rs1801131	CC vs. AA	2.83 (1.30–6.16)	0.009	MO	159/1477	0.916	0.998	0.752	0.994	0.991	0.998
Liu H, 2011 [23]	5-HTT/VNTR	12/other	1.30 (1.02–1.67)	0.037	MO	319/697	0.741	0.993	0.467	0.979	0.887	0.998
Liu H, 2011 [23]	5-HTT/VNTR	12/12 vs. 12/other +other	1.55 (1.11–2.16)	0.010	MO	319/697	0.737	0.993	0.302	0.958	0.801	0.995
Schurks M, 2010 [20]	ACE/rs1799752	II vs. ID + DD	0.84 (0.70–0.99)	0.049	MO	2853/22310	0.570	0.986	0.417	0.974	0.888	0.998

MA migraine with aura, MO migraine without aura

Back to article page

ISSN: 1129-2377

Contact us

Submission enquiries: journalsubmissions@springernature.com