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Table 3 Subgroup analysis of genetic variants with statistically significance (P-value< 0.05) from observational studies based on migraine subtype

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, yearGene/variantComparisonOR (95%CI)P-valueSubtypesNo. of cases/controlsFPRP Values at Prior probabilityBFDP 0.05BFDP 0.001
OR 1.2OR 1.5
0.050.0010.050.001
Liu L, 2019 [48]MTHFR/rs1801133T vs. C1.28 (1.09–1.51)0.003MA4313/280920.2260.9390.0630.7780.5600.985
Liu L, 2019 [48]MTHFR/rs1801133CT + TT vs. CC1.20 (1.00–1.44)0.049MA4313/280920.6550.9900.4890.9810.9040.998
Liu L, 2019 [48]MTHFR/rs1801133TT vs. CT + CC1.46 (1.10–1.95)0.010MA4313/280920.6820.9910.2560.9480.7880.995
Liu L, 2019 [48]MTHFR/rs1801133TT vs. CC1.51 (1.09–2.08)0.012MA4313/280920.7350.9930.3140.9600.8120.996
Terrazzino S, 2017 [44]BDNF/rs6265GA + AA vs. GG1.22 (1.00–1.47)0.047MA717/15930.6170.9880.4130.9740.8820.997
Li L, 2015 [37]ESR1/rs1801132GG vs. CC1.59 (1.17–2.15)0.003MA1427/19190.5930.9870.1230.8800.6320.989
Li L, 2015 [37]ESR1/rs1801132GG vs. CG + CC1.58 (1.18–2.13)0.002MA1427/19190.5900.9870.1220.8800.6330.989
Chen M, 2015 [35]TNF-α/rs1800629AA+GA vs. GG1.17 (1.05–1.30)0.004MA1763/218370.0890.8370.0620.7770.5820.987
Chen M, 2015 [35]TNF-α/rs1800629A vs. G1.13 (1.03–1.24)0.010MA1763/218370.1730.9170.1590.9080.7830.995
Chen M, 2015 [35]TNF-α/rs1800629GA vs. GG1.17 (1.05–1.31)0.005MA1763/218370.1150.9060.1100.8660.6940.992
Chen M, 2015 [35]NOS3/rs1799983TT vs. GG1.61 (1.12–2.31)0.010MA440/8810.7700.9940.3450.9650.8160.996
Chen M, 2015 [35]NOS3/rs1799983TT vs. GT + GG1.50 (1.08–2.09)0.016MA440/8810.7710.9940.3870.9710.8430.996
Liu H, 2011 [23]5-HTT/VNTR12/other1.33 (1.01–1.75)0.042MA176/6290.7740.9940.4960.9810.8910.998
Liu H, 2011 [23]5-HTT/VNTR12/12 vs. 12/other +other1.58 (1.07–2.33)0.021MA176/6290.8290.9960.5010.9810.8730.997
Schurks M, 2010 [20]ACE/rs1799752II vs. ID + DD0.71 (0.55–0.93)0.011MA1761/223100.6670.9910.2660.9500.8010.995
Liu L, 2019 [48]MTHFR/rs1801131C vs. A1.43 (1.06–1.92)0.018MO159/14770.7300.9930.3450.9650.8350.996
Liu L, 2019 [48]MTHFR/rs1801131CC vs. AC + AA2.74 (1.46–5.14)0.002MO159/14770.8640.9970.5150.9820.8420.996
Liu L, 2019 [48]MTHFR/rs1801131CC vs. AA2.83 (1.30–6.16)0.009MO159/14770.9160.9980.7520.9940.9910.998
Liu H, 2011 [23]5-HTT/VNTR12/other1.30 (1.02–1.67)0.037MO319/6970.7410.9930.4670.9790.8870.998
Liu H, 2011 [23]5-HTT/VNTR12/12 vs. 12/other +other1.55 (1.11–2.16)0.010MO319/6970.7370.9930.3020.9580.8010.995
Schurks M, 2010 [20]ACE/rs1799752II vs. ID + DD0.84 (0.70–0.99)0.049MO2853/223100.5700.9860.4170.9740.8880.998
  1. MA migraine with aura, MO migraine without aura
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