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Table 2 Meta-analyses results of genetic variants with statistically significance (P-value< 5*10−8) from GWAS

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, yearGene/variantComparisonOR (95%CI)P-ValueEthnicityNo. of cases/controlsFPRP Values at Prior probabilityBFDP 0.001BFDP 0.000001
OR 1.2OR 1.5
0.0010.0000010.0010.000001
Chang X, 2018 [45]NMUR2/rs1946225G vs. T2.29 (1.73–3.05)9.55E-09Overall 3 (European 1, African 2)1212/134940.7171.0000.0060.8510.0270.965
Chang X, 2018 [45]NMUR2/rs72793414A vs. G2.44 (1.85–3.23)3.81E-10Overall 3 (European 1, African 2)1212/134940.5450.9990.0010.5410.0030.743
Gormley P, 2016 [40]LRP1/rs11172113C vs. T0.90 (0.89–0.91)5.6E-49Overall (Caucasian 22)59,674/3160786.004E-726.011E-69
Gormley P, 2016 [40]PRDM16/rs10218452G vs. A1.11 (1.10–1.13)5.3E-38Overall (Caucasian 22)59,674/3160788.348E-258.356E-22
Gormley P, 2016 [40]FHL5/rs67338227T vs. A1.09 (1.08–1.11)2.0E-27Overall (Caucasian 22)59,674/3160784.430E-154.435E-12
Gormley P, 2016 [40]TSPAN2/rs2078371C vs. T1.11 (1.09–1.13)4.1E-24Overall (Caucasian 22)59,674/3160788.348E-258.356E-22
Gormley P, 2016 [40]TRPM8/rs10166942C vs. T0.94 (0.89–0.99)1.0E-23Overall (Caucasian 22)59,674/3160780.9511.0000.9511.0000.9981.000
Gormley P, 2016 [40]PHACTR1/rs9349379G vs. A0.93 (0.92–0.95)5.8E-22Overall (Caucasian 22)59,674/3160782.308E-082.310E-052.308E-082.310E-054.007E-063.995E-03
Gormley P, 2016 [40]MEF2D/rs1925950A vs. G1.07 (1.06–1.09)9.1E-22Overall (Caucasian 22)59,674/3160788.014E-108.022E-078.014E-108.022E-071.694E-071.695E-04
Gormley P, 2016 [40]SLC24A3/rs4814864C vs. G1.07 (1.06–1.09)2.2E-19Overall (Caucasian 22)59,674/3160788.014E-108.022E-078.014E-108.022E-071.694E-071.695E-04
Gormley P, 2016 [40]FGF6/rs1024905A vs. G1.06 (1.04–1.08)2.1E-17Overall (Caucasian 22)59,674/3160789.959E-079.959E-049.959E-079.959E-041.767E-040.150
Gormley P, 2016 [40]C7orf10/rs186166891T vs. A1.09 (1.07–1.12)9.7E-16Overall (Caucasian 22)59,674/3160784.993E-074.935E-044.993E-074.935E-046.430E-056.048E-02
Gormley P, 2016 [40]PLCE1/rs10786156G vs. C0.95 (0.94–0.96)2.0E-14Overall (Caucasian 22)59,674/3160783.842E-163.846E-13
Gormley P, 2016 [40]KCNK5/rs10456100T vs. C1.06 (1.04–1.07)6.9E-13Overall (Caucasian 22)59,674/3160783.372E-283.376E-25
Gormley P, 2016 [40]ASTN2/rs6478241T vs. A1.05 (1.04–1.07)1.2E-12Overall (Caucasian 22)59,674/3160784.011E-040.2874.011E-040.2870.0550.983
Gormley P, 2016 [40]MRVI1/rs4910165G vs. C0.94 (0.91–0.98)2.9E-11Overall (Caucasian 22)59,674/3160780.7831.0000.7831.0000.9931.000
Gormley P, 2016 [40]HPSE2/rs12260159A vs. G0.92 (0.89–0.94)3.2E-10Overall (Caucasian 22)59,674/3160782.979E-112.982E-082.979E-112.982E-085.906E-095.912E-06
Gormley P, 2016 [40]CFDP1/rs77505915A vs. T1.05 (1.03–1.06)3.3E-10Overall (Caucasian 22)59,674/3160783.476E-183.479E-15
Gormley P, 2016 [40]RNF213/rs17857135C vs. T1.06 (1.04–1.08)5.2E-10Overall (Caucasian 22)59,674/3160789.959E-079.959E-049.959E-079.959E-041.767E-040.150
Gormley P, 2016 [40]NRP1/rs2506142G vs. A1.06 (1.04–1.07)1.5E-09Overall (Caucasian 22)59,674/3160783.372E-283.376E-25
Gormley P, 2016 [40]GPR149/rs13078967C vs. A0.87 (0.83–0.91)1.8E-09Overall (Caucasian 22)59,674/3160781.300E-061.299E-031.260E-061.260E-031.117E-040.101
Gormley P, 2016 [40]JAG1/rs111404218G vs. C1.05 (1.03–1.07)2.0E-09Overall (Caucasian 22)59,674/3160784.011E-040.2874.011E-040.2870.0550.983
Gormley P, 2016 [40]SPINK2/rs7684253T vs. C0.96 (0.94–0.97)2.5E-09Overall (Caucasian 22)59,674/3160781.153E-111.154E-081.153E-111.154E-084.525E-094.530E-06
Gormley P, 2016 [40]ZCCHC14/rs4081947G vs. A1.03 (1.00–1.06)2.5E-09Overall (Caucasian 22)59,674/3160780.9781.0000.9781.0001.0001.000
Gormley P, 2016 [40]HEY2/rs1268083C vs. T0.96 (0.95–0.97)5.3E-09Overall (Caucasian 22)59,674/3160781.153E-111.154E-081.153E-111.154E-084.525E-094.530E-06
Gormley P, 2016 [40]WSCD1/rs75213074T vs. C0.89 (0.86–0.93)7.1E-09Overall (Caucasian 22)59,674/3160782.044E-040.1702.040E-040.1700.0150.937
Gormley P, 2016 [40]GJA1/rs28455731T vs. G1.06 (1.04–1.08)7.3E-09Overall (Caucasian 22)59,674/3160789.959E-079.959E-049.959E-079.959E-041.767E-040.150
Gormley P, 2016 [40]TGFBR2/rs6791480T vs. C1.04 (1.03–1.06)7.8E-09Overall (Caucasian 22)59,674/3160780.0520.9820.0520.9820.8631.000
Gormley P, 2016 [40]ITPK1/rs11624776C vs. A0.96 (0.94–0.97)7.9E-09Overall (Caucasian 22)59,674/3160781.153E-111.154E-081.153E-111.154E-084.525E-094.530E-06
Gormley P, 2016 [40]ADAMTSL4/rs6693567T vs. C1.05 (1.03–1.06)1.2E-08Overall (Caucasian 22)59,674/3160783.476E-183.479E-15
Gormley P, 2016 [40]CCM2L/rs144017103T vs. C0.85 (0.76–0.96)1.2E-08Overall (Caucasian 22)59,674/3160780.9341.0000.8991.0000.9931.000
Gormley P, 2016 [40]YAP1/rs10895275A vs. T1.04 (1.03–1.06)1.6E-08Overall (Caucasian 22)59,674/3160780.0520.9820.0520.9820.8631.000
Gormley P, 2016 [40]MED14/rs12845494G vs. C0.96 (0.95–0.97)1.7E-08Overall (Caucasian 22)59,674/3160781.153E-111.154E-081.153E-111.154E-084.525E-094.530E-06
Gormley P, 2016 [40]DOCK4/rs10155855T vs. A1.08 (1.05–1.12)2.1E-08Overall (Caucasian 22)59,674/3160780.0320.9710.0320.9710.6881.000
Gormley P, 2016 [40]LRRIQ3/rs1572668G vs. A1.04 (1.02–1.05)2.1E-08Overall (Caucasian 22)59,674/3160788.873E-138.882E-108.873E-138.882E-104.186E-104.190E-07
Gormley P, 2016 [40]CARF/rs138556413G vs. A0.88 (0.84–0.92)2.3E-08Overall (Caucasian 22)59,674/3160781.748E-050.0171.733E-050.0171.395E-030.583
Gormley P, 2016 [40]ARMS2/rs2223089C vs. G0.93 (0.91–0.95)3.0E-08Overall (Caucasian 22)59,674/3160782.308E-082.310E-052.308E-082.310E-054.007E-063.995E-03
Gormley P, 2016 [40]IGSF9B/rs561561T vs. A0.94 (0.92–0.96)3.4E-08Overall (Caucasian 22)59,674/3160788.384E-060.0088.384E-060.0081.254E-030.557
Gormley P, 2016 [40]MPPED2/rs11031122C vs. T1.04 (1.03–1.06)3.5E-08Overall (Caucasian 22)59,674/3160780.0520.9820.0520.9820.8631.000
Gormley P, 2016 [40]NOTCH4/rs140002913A vs. G0.91 (0.88–0.94)3.8E-08Overall (Caucasian 22)59,674/3160781.204E-050.0121.204E-050.0121.229E-030.552
Anttila V, 2013 [29]PRDM16/rs2651899C vs. T1.09 (1.07–1.12)3.28E-14Overall (Caucasian 19)23,285/954254.933E-074.935E-044.933E-074.935E-046.430E-050.0605
Anttila V, 2013 [29]TSPAN2/rs12134493A vs. C1.14 (1.10–1.18)6.71E-14Overall (Caucasian 19)23,285/954259.555E-119.565E-089.538E-119.548E-081.305E-081.307E-05
Anttila V, 2013 [29]MEF2D/rs2274316C vs. A1.07 (1.04–1.09)3.14E-08Overall (Caucasian 19)23,285/954258.014E-108.022E-078.014E-108.022E-071.694E-071.695E-04
Anttila V, 2013 [29]TRPM8/rs7577262A vs. G0.87 (0.84–0.90)3.27E-13Overall (Caucasian 19)23,285/954258.231E-138.239E-108.180E-138.188E-101.259E-101.260E-07
Anttila V, 2013 [29]FHL5/rs13208321A vs. T1.18 (1.13–1.24)2.15E-12Overall (Caucasian 19)23,285/954258.181E-088.189E-056.109E-086.115E-055.781E-065.753E-03
Anttila V, 2013 [29]c7orf10/rs4379368T vs. C1.11 (1.08–1.15)1.46E-09Overall (Caucasian 19)23,285/954257.560E-067.511E-037.560E-067.511E-037.339E-040.424
Anttila V, 2010 [16]MTDH/rs1835740C vs. T1.18 (1.13–1.24)1.60E-11Overall (Caucasian 7)5950/508091.109E-061.109E-038.138E-078.139E-046.811E-050.064
  1. GWAS genome-wide association studies, OR odds radio, CI confidence interval, FPRP false-positive rate probability, BFDP Bayesian false discovery probability
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