Table 1 Studies reporting humanistic burden of migraine
Citation | Country/ region | Study design Study dates Migraine criteria | Migraine criteria | Migraine (n) Age, y % F | Main findings for participants with migraine |
|---|---|---|---|---|---|
Yu, 2012 [29] | China / Mainland | Population-based 2009 | ICHD-II | 469 Mean 46.2 y 67.6 F | World Health Organization QoL-8 (migraine [n = 464] vs no headache; P < 0.05 for all comparisons): • Total score 25.7 vs 27.9 • Life quality 3.2 vs 3.4 • Health level 3.0 vs 3.6 • Daily life ability 3.4 vs 3.7 • Satisfied with yourself 3.5 vs 3.7 • Interpersonal relationships 3.8 vs 3.9 • Habitation condition 3.3 vs 3.5 • Daily life energy 3.0 vs 3.4 • Payment ability 2.6 vs 2.8 |
Wang, 2016 [27] | China / Mainland | Population-based 2013 | ID Migraine Screener – Chinese version | 102 Mean 51.5 y 84.3 F | HRQoL (SF-36) was significantly worse for respondents with migraine than those without. Domains significantly different (linear regression, P < 0.05) were: • Role physical −25.8 mean difference • Role emotional − 17.1 • General health − 13.0 • Bodily pain − 10.9 • Physical functioning − 3.8 |
Hung, 2006 [34] | China / Taiwan | Cross-sectional-other: headache clinic 2003–2004 | ICHD-II | 281 adults Mean 35.3 y 20–50 y 77.6 F | MIDAS-T Mean score: 34.2 ± 45.9 (severe disability) • Days missed from work/school 4.6 ± 9.9 • Reduced effectiveness days at work/school 8.2 ± 12.2 • Days missed from housework 7.1 ± 14.0 • Reduced effectiveness in housework 8.0 ± 12.1 • Days missed from family, social, or leisure activities 6.5 ± 13.9 |
Wang, 2013 [46] | China / Taiwan | Cross-sectional other: headache clinics 2011 | Neurologist diagnosis / ICHD-II | 331 adults Mean, 41 77.7 F | MIDAS scores for chronic migraine vs episodic migraine: • 46.1 ± 49.2 (grade IV–B) vs EM: 14.4 ± 23.4 (grade III), P < 0.001% MIDAS with severe disability: 59.3% vs 21.9% • % MIDAS with very severe disability: 41.3% vs 7.9% MSQ for chronic migraine vs episodic migraine: • Role function restrictive (56.4 ± 17.3 vs 70.8 ± 13.8, P < 0.001) • Role function preventive (70.0 ± 18.2 vs 81.4 ± 16.2, P < 0.001) • Emotional function scores (62.0 ± 23.0 vs 78.1 ± 16.8, P < 0.001) EQ-5D VAS chronic migraine vs episodic migraine: • 67.4 ± 18.7 vs 82.3 ± NR, P < 0.001 |
Wang, 2001 [42] | China / Taiwan | Cross-sectional other: headache clinic 1998–1999 | IHS | 193 adults Mean 41.8 y 80 F | Compared with SF-36 normative data (0–100) for Taiwanese women, migraine had the greatest effect on bodily pain and role emotional: • Role physical 77.6 vs 56.0 • Bodily pain 79.4 vs 49.7 • General health 63.3 vs 49.5 • Vitality 65.3 vs 50.9 • Social functioning 85.3 vs 67.9 • Role emotional 79.9 vs 54.2 • Mental health 71.8 vs 61.6 |
Sakai, 1997 [51] | Japan | Population-based NR | IHS | 338 adults ≥15 y 79.0 F | 74.2% had significant impairment in daily living (not defined): • Disability in social activity: severe (4.5%), moderate (27.5%), mild/none (68.0%) • Daily activity impairment: required bedrest always (4%), frequently required bedrest with severely impaired daily activity (30%), moderate impairment of daily activity (40%), minor impairment (21%), no impairment (5%) |
Iigaya, 2003 [49] | Japan | Cross-sectional other: headache clinics 2000 | IHS | 99 patients with migraine and or TTH (72% had at least migraine) Mean 42.7 y 80.8 F | 46.5% of patients were MIDAS grade I or II (minimal, mild, or infrequent disability), 22.2% were MIDAS grade III (moderate disability), and 31.3% were MIDAS grade IV (severe disability) |
Roh, 1998 [59] | South Korea | Population-based 1996 | IHS | 272 adults ≥15 y 24.3 F | 19.1% discontinued daily activities because of migraine 34.4% canceled work or social activities because of migraine |
South Korea | Population-based 2009 | ICHD-II | 92 adults ≥19 y NR | Mean HIT-6 scores: 51.9 for women and 51.8 for men • Little or no impact, 42.8%–42.9% • Some impact, 25.3%–25.7% • Substantial impact, 13.0%–13.2% • Severe impact, 18.5%–18.7% Over the past 3 mo, patients with migraine experienced: • Restriction in activities for a mean of 2.7 days • Missing activities for a mean of 2.8 days | |
Adolescents/children | |||||
Lu, 2000 [36] | China / Taiwan | Population-based 1998–1999 | IHS | 277 adolescents 13–15 y 58.8 F | 30.4% of children with migraine were absent from school because of headache in the previous semester: 1–3 days 27%, ≥4 days 3.4% |
Goto, 2017 [48] | Japan | Population-based 2012 | IHS | 131 adolescents 6–12 y: 42.5 F 12–15 y: 67.2 F | Feeling fed up or irritated, having difficulty concentrating were significantly more common (P = 0.010 and P = 0.017, respectively) in migraine than TTH For children with migraine, the number of days for the past 3 mo that disability affected school life, including school absences, arriving late, leaving early, or having difficulty participating in physical activities, ranged from 1.7 (SD 1.2) days to 3.8 (SD 3.7) days |