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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

Fig. 2

Electrophysiological analysis of 5 FHM3 mutations in HEK cells. a-f show typical voltage clamp current traces in response to the standard IV protocol. Scale bars: 2 ms and 500 pA, respectively. g shows the peak current density and h the time constant of recovery from inactivation at − 90 mV. i show the relative persistent current. Values for mutants F1499 L and Q1489H are significantly larger than those of WT (p < 0.001) at all voltages. Values for mutants F1661 L and M1500 V are statistically significantly different from those of WT only at − 40 mV (p < 0.05)

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