Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

Table 4 Significant inter-group ICA differences between CADASIL patients and controls

Predominant cluster regions	Cluster size	Peak T value	MNI coordinates			Cluster level PFWE-corr
Predominant cluster regions	Cluster size	Peak T value	x	y	z	Cluster level PFWE-corr
CADASIL < controls in VIN
Bilateral LG	348	−6.19	−9	−78	−3	0.000
Right CU	348	−6.19	−9	−78	−3	0.000
CADASIL < controls in FRN
Right Pcu	59	−5.18	24	−57	36	0.002
Right IFG	67	−5.05	48	3	21	0.001
Right precentral gyrus	67	−5.05	48	3	21	0.001

The surviving ICA clusters were assigned thresholds of p < 0.001 and FWE-corrected to p < 0.05 at the cluster level
ICA Independent component analysis, CADASIL Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, MNI Montreal Neurological Institute, FWE Family wise errors, VIN Visual network, LG Lingual gyrus, CU Cuneus, FRN Frontal network, Pcu Precuneus, IFG Inferior frontal gyrus

ISSN: 1129-2377