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Table 4 Burden of illness in patients with episodic migraine and chronic migraine: patient self-completion form data

From: Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme

Patient-reported outcomes Cohort Total
(N = 634)
p-value
Episodic migraine
0–3 HDM
(n = 331)
Episodic migraine
4–7 HDM
(n = 183)
Episodic migraine
8–14 HDM
(n = 86)
Chronic migraine
≥15 HDM
(n = 34)
MIDAS total score, mean (SD) 4.8 (12.6) 11.0 (26.2) 15.7 (18.3) 21.3 (22.0) 8.9 (19.4) < 0.001a
MIDAS disability category, n (%)       < 0.001b
 Little/no disability 191 (74.9) 86 (57.7) 29 (39.7) 6 (30.0) 312 (62.8)  
 Mild disability 32 (12.5) 25 (16.8) 14 (19.2) 2 (10.0) 73 (14.7)  
 Moderate disability 20 (7.8) 17 (11.4) 7 (9.6) 5 (25.0) 49 (9.9)  
 Severe disability 12 (4.7) 21 (14.1) 23 (31.5) 7 (35.0) 63 (12.7)  
Derived Japanese EQ-5D utility score, mean (SD) 0.89 (0.16) 0.86 (0.18) 0.82 (0.19) 0.72 (0.23) 0.86 (0.18) < 0.001a
EQ-5D overall VAS score, mean (SD) 73.8 (17.9) 72.5 (16.9) 68.8 (18.4) 60.8 (22.6) 72.1 (18.2) < 0.001a
WPAI score, mean (SD)
 % Work time missed 4.5 (16.1) 4.4 (13.3) 2.8 (9.7) 8.5 (18.6) 4.4 (14.6) 0.562a
 % Impairment at work 29.5 (25.5) 35.8 (27.6) 37.3 (29.4) 42.2 (25.1) 33.0 (26.9) 0.051a
 % Overall work impairment 30.5 (26.7) 37.0 (28.9) 38.1 (29.4) 44.7 (28.0) 34.2 (28.0) 0.058a
 % Activity impairment 32.4 (28.0) 40.1 (28.0) 46.1 (28.8) 55.0 (28.0) 37.7 (28.8) < 0.001a
  1. Continuous variables are reported as mean (SD) for non-missing observations; percentages are calculated as proportion of non-missing data. MIDAS score 0–5 = little or no disability; MIDAS score 6–10 = mild disability; MIDAS score 11–20 = moderate disability; MIDAS score > 21 = severe disability; higher EQ-5D utility and VAS scores indicate higher general health status and quality of life, respectively
  2. EQ-5D, EuroQol-5 Dimensions; HDM, headache days per month; MIDAS, Migraine Disability Assessment; SD, standard deviation; VAS, visual analog scale; WPAI, Work Productivity and Activity Impairment
  3. aAnalysis of variance analyses
  4. bFisher’s exact test
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