Table 5 Response to OnabotA. Statistical analysis

Genes related to glutamate homeostasis

MEF2D

rs1050316

G > T

0.907

0.729

0.836

0.665

LRP1

rs11172113

T > C

0.583

0.439

0.963

0.319

MTDH

rs1835740

A > G

0.596

0.740

0.527

0.543

EAAT2

rs4354668

T > G

0.266

0.105

0.147

0.231

GRIK3

rs6691840

A > C

0.218

0.176

0.088

0.397

CGRP

CALCA

rs3781719

T > C

0.023

0.029

0.794

0.007

rs145837941

A > G

–

–

–

–

GABA

Receptor system

GABRE

rs1139916

A > C

0.312

0.522

0.977

0.148

GABRQ

rs3810651

A > T

0.824

0.532

0.619

0.604

GABRA3

rs6627221

T > C

0.271

0.190

0.977

0.074

rs2201169

T > C

0.381

0.195

0.436

0.205

Voltage dependent channels

SCN9A

rs6746030

G > A

0.400

0.603

0.367

0.419

KCNS1

rs734784

A > G

0.615

0.458

0.854

0.333

P2RX7

rs2230912

A > G

0.972

0.863

0.950

0.837

rs1718119

C > T

0.628

0.584

0.351

0.916

Dopamine receptor

DRD2

rs1800497

C > T

0.775

0.699

0.773

0.569

Serotoninergic receptor

HTR2C

rs3813929

C > T

0.332

0.163

0.675

0.139

TRPfamily

TRPV1

rs222749

G > A

0.040

0.021

0.013

0.102

rs222747

G > C

0.749

0.740

0.459

0.958

rs222741

C > T

0.922

0.777

0.843

0.698

TRPV3

rs7217270

A > G

0.553

0.275

0.446

0.317

TRPM8

rs10166942

T > C

0.656

0.655

0.361

0.873

Others

WFS1

rs734312

G > A

0.767

0.655

0.498

0.989

TGFBR2

rs7640543

G > A

0.925

0.920

0.729

0.929

MTHFR

rs121434294

C > T

–

–

–

–