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Table 5 Response to OnabotA. Statistical analysis

From: CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA

FAMILY GENE SNP p
CHANGE ANALYSIS
BY PHENOTYPE
ALLELE
FREQUENCY
ALLELE VARIANT RECESIVITY HYPOTHESIS ALLELE VARIANT DOMINANCE HYPOTHESIS
Genes related to glutamate homeostasis MEF2D rs1050316 G > T 0.907 0.729 0.836 0.665
LRP1 rs11172113 T > C 0.583 0.439 0.963 0.319
MTDH rs1835740 A > G 0.596 0.740 0.527 0.543
EAAT2 rs4354668 T > G 0.266 0.105 0.147 0.231
GRIK3 rs6691840 A > C 0.218 0.176 0.088 0.397
CGRP CALCA rs3781719 T > C 0.023 0.029 0.794 0.007
rs145837941 A > G
GABA
Receptor system
GABRE rs1139916 A > C 0.312 0.522 0.977 0.148
GABRQ rs3810651 A > T 0.824 0.532 0.619 0.604
GABRA3 rs6627221 T > C 0.271 0.190 0.977 0.074
rs2201169 T > C 0.381 0.195 0.436 0.205
Voltage dependent channels SCN9A rs6746030 G > A 0.400 0.603 0.367 0.419
KCNS1 rs734784 A > G 0.615 0.458 0.854 0.333
P2RX7 rs2230912 A > G 0.972 0.863 0.950 0.837
rs1718119 C > T 0.628 0.584 0.351 0.916
Dopamine receptor DRD2 rs1800497 C > T 0.775 0.699 0.773 0.569
Serotoninergic receptor HTR2C rs3813929 C > T 0.332 0.163 0.675 0.139
TRPfamily TRPV1 rs222749 G > A 0.040 0.021 0.013 0.102
rs222747 G > C 0.749 0.740 0.459 0.958
rs222741 C > T 0.922 0.777 0.843 0.698
TRPV3 rs7217270 A > G 0.553 0.275 0.446 0.317
TRPM8 rs10166942 T > C 0.656 0.655 0.361 0.873
Others WFS1 rs734312 G > A 0.767 0.655 0.498 0.989
TGFBR2 rs7640543 G > A 0.925 0.920 0.729 0.929
MTHFR rs121434294 C > T
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