CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA

Table 3 Association between response to OnabotA and SNP rs222749 in gene TRPV1

						P value				Odds ratio (95% CI)
POPULATION	RESPONSE	GENOTYPES			MINOR ALLELE FREQUENCY (%)	GENOTYPIC FREQUENCY	ALLELE FREQUENCY	ALLELE A RECESIVITY HYPOTHESIS	ALLELE A DOMINANCE HYPOTHESIS	Dominant model	Codominant model	Recessive model
POPULATION	RESPONSE	GG	GA	AA	MINOR ALLELE FREQUENCY (%)	GENOTYPIC FREQUENCY	ALLELE FREQUENCY	ALLELE A RECESIVITY HYPOTHESIS	ALLELE A DOMINANCE HYPOTHESIS	Dominant model	Codominant model	Recessive model
n = 156	Responders (n = 120)	111	8	1	4,2	0,040	0,021	0,013	0,102	2,47 (0,81-7,48)	2,40 (0,80-7,24)	10,82 (1,09-107,45)
n = 156	Non-responders (n = 36)	30	3	3	12,5	0,040	0,021	0,013	0,102	2,47 (0,81-7,48)	2,40 (0,80-7,24)	10,82 (1,09-107,45)

ISSN: 1129-2377