Fig. 2

Perampanel reduces in significant manner CGRP release stimulated by 56 mM KCl from rat brainstem explants. Data are expressed as CGRP ratio (see “Materials & Methods” section), the means ±1 S.E.M. of 9 replicates per group. In the figure, asterisks refer to statistical comparisons of each experimental group versus unstimulated controls, whereas circles refer to statistical comparisons of each experimental group versus secretagogue-stimulated controls. In particular, *, ** and ***: p < 0.05, p < 0.01 and p < 0.001 vs Control respectively; °° and °°°: p < 0.01 and p < 0.001 vs the secretagogue given alone, respectively