Polarity-specific modulation of pain processing by transcranial direct current stimulation – a blinded longitudinal fMRI study

Table 2 Effect of tDCS on trigeminal nociceptive processing

MNI X Y Z	Anatomical area		k_E	T	p_FWE cluster	p_FWE peak
−22 8–16	L	Amygdala^a	107	4.48	.005	.001
−12 2 4	L	Basal ganglia^a	208	4.24	.033	.006
26 0–20	R	Amygdala^a	125	4.18	.002	.001
56–30 -8	R	Mid. temporal gyrus	74	4.17	NA	NA
−10 -28 70	L	M1 and premotor cortex^a	162	4.11	.010	.012
−14 -10 18	L	Thalamus^a	39	3.99	.015	.008
56–18 6	R	Superior temporal gyrus	86	3.97	NA	NA
14 4 6	R	Basal ganglia^a	94	3.93	.027	.029
−50 -32 12	L	Superior temporal gyrus	49	3.85	NA	NA
66–8 18	R	Postcentral gyrus^a	24	3.81	.042	.025
−40 -2 -18	L	Posterior Insular cortex	27	3.77	NS	NS
−6 -4 44	L	Cingulate cortex^a	47	3.77	.03	.027
10–24 74	R	Suppl. motor/premotor cortex	25	3.73	NS	NS
4 14 0	R	Basal ganglia / Caudate ncl.^a	59	3.68	.027	.032
38 2 54	R	DLPFC^a	44	3.67	.044	.047
44 42 4	R	DLPFC	42	3.58	NS	NS

Areas with significant DC-stimulation induced alterations (postcathodal vs. postanodal). Illustration in Fig. 2. Exploratory significance level p_unc < .0005. Additional region of interest analysis (ROI) with applied Family-Wise-Error correction for the neuropain-matrix as indicated in the materials and method section (^ap_FWE < 0.05)
R = right, L = left, BL = bilateral, Ke = cluster extend, MNI = Montreal Neurological Institute: NA = not applicable, NS = not significant. M1 = primary motorcortex, DLPFC = dorsolateral prefrontal cortex

ISSN: 1129-2377