Table 1 Epidemiological and genetic similarities and differences in migraine and cluster headache
Migraine | Cluster headache | ||
|---|---|---|---|
Epidemiology and genetics | Similarities | ||
Familial aggregation [6] | Familial aggregation [7] | ||
12-15% of the general population [2] | 0.5-1 ‰ of the general population [4] | Differences | |
The first-degree relatives of patients have a 3-fold increase of migraine headache, compared with the general population [14] | The risk of first-degree relatives of patients to develop CH is between five and fifteen times greater than that of the general population [7] | ||
Supposed mode of inheritance | Polygenic disorder and rare monogenic variants [15] | Autosomal dominant with incomplete penetrance, multifactorial or autosomal recessive [12, 13] |