Table 1 Relaxant responses to CGRP in the presence or absence of 66.7 nM fremanezumab or its isotype control
Abdominal arteries | Intracranial arteries | |||
|---|---|---|---|---|
Imax (%) | IC50 (nM) | Imax (%) | IC50 (nM) | |
CGRP control curve | 82 ± 4 | 2.1 ± 0.1 | 78 ± 22 | 1.1 ± 0.5 |
+ fremanezumab 66.7 nM | 71 ± 3 | 182 ± 1.0 | 49 ± 11 | 752 ± 9 |
+ isotype control 66.7 nM | 71 ± 9 | 3.2 ± 0.2 | 55 ± 12 | 2.9 ± 0.4 |