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Table 3 Incidence and hazard ratios of mortality stratified by age, sex, and comorbidity for patients with migraine comparing with those without migraine

From: Survival outcome and mortality rate in patients with migraine: a population-based cohort study

 

Comparison

N = 79,246

Migraine

Total

N = 19,817

Status migrainosus

N = 5868

Non-status migraine

N = 13,949

Event no

Rate

Event no

Rate

HRa (95% CI)

Event no

Rate

HRa (95% CI)

Event no

Rate

HRa (95% CI)

Age, year

 20–49

1495

3.94

258

2.70

0.68(0.60, 0.78)***

91

3.13

0.79(0.64,0.98)*

167

2.51

0.64(0.54, 0.75)***

 50–64

1373

10.0

294

8.54

0.85(0.75, 0.96)**

86

8.53

0.85(0.68, 1.06)

208

8.55

0.85(0.73, 0.98)*

 65+

2799

42.6

615

36.7

0.86(0.79, 0.94)***

224

42.0

0.97(0.85, 1.11)

391

34.2

0.81(0.73, 0.90)***

Sex

 Female

3090

7.19

603

5.57

0.78(0.71, 0.85)***

205

6.39

0.88(0.77, 1.02)

398

5.22

0.73(0.66, 0.81)***

 Male

2577

16.9

564

14.7

0.86(0.78, 0.94)**

196

15.8

0.89(0.77, 1.03)

368

14.1

0.84(0.75, 0.94)**

Comorbidity

 None

986

7.56

172

5.20

0.69(0.59, 0.81)***

68

5.52

0.73(0.57, 0.94)*

104

5.02

0.66(0.54, 0.81)***

 With any one

4681

10.4

995

8.75

0.84(0.79, 0.90)***

333

10.4

1.00(0.89, 1.11)

662

8.12

0.78(0.72, 0.85)***

  1. Rate per 1000 person-years
  2. a: multivariable analysis including age, sex, and comorbidities of depression, mental disorders, insomnia, alcohol-related illness, and anxiety
  3. *P < 0.05, **P < 0.01, ***P < 0.001