|  |  | Without pharmacotherapy | With pharmacotherapy | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | Migraine | N | HAMD | HADS-A | HI | HF | N | HAMD | HADS-A | HI | HF |
Baseline | Yes | 136 | 24.8 ± 4.3** | 15.7 ± 3.2** | 6.4 ± 3.0** | 4.3 ± 2.4** | − | − | − | − | − |
Baseline | No | 154 | 22.2 ± 3.8 | 14.3 ± 3.3 | 3.2 ± 2.7 | 2.3 ± 2.2 | − | − | − | − | − |
Six month | Yes | 58 | 14.2 ± 9.1* | 10.0 ± 5.0 | 3.7 ± 3.0** | 2.8 ± 2.5** | 60 | 10.5 ± 6.7** | 9.1 ± 4.5** | 2.9 ± 2.8** | 2.2 ± 2.0*** |
Six month | No | 75 | 11.0 ± 7.8 | 9.2 ± 4.7 | 1.5 ± 1.8 | 1.5 ± 2.2 | 61 | 6.7 ± 5.8 | 6.1 ± 4.1 | 1.4 ± 2.0 | 0.9 ± 1.4 |
Two year | Yes | 34 | 16.3 ± 7.3** | 12.0 ± 4.4** | 5.2 ± 3.0** | 2.6 ± 2.2** | 20 | 15.7 ± 6.4** | 11.9 ± 3.7** | 4.8 ± 2.9** | 2.6 ± 2.0** |
Two year | No | 138 | 8.4 ± 6.6 | 7.9 ± 4.1 | 1.5 ± 2.0 | 1.0 ± 1.5 | 45 | 9.6 ± 6.8 | 8.7 ± 4.3 | 2.3 ± 2.3 | 1.6 ± 1.8 |
Ten year | Yes | 38 | 10.4 ± 5.5** | 8.7 ± 4.8* | 3.9 ± 3.0** | 1.6 ± 1.5** | 14 | 16.0 ± 6.8* | 13.4 ± 4.5** | 4.5 ± 3.5** | 3.2 ± 2.7** |
Ten year | No | 61 | 6.4 ± 5.3 | 6.6 ± 4.1 | 1.3 ± 2.1 | 1.0 ± 1.5 | 24 | 11.3 ± 6.2 | 9.6 ± 3.7 | 1.3 ± 2.0 | 1.2 ± 1.7 |