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Table 3 The difference of psychometric scores and headache indices at four time points between patients with and without migrainea

From: Migraine and greater pain symptoms at 10-year follow-up among patients with major depressive disorder

   

Without pharmacotherapy

With pharmacotherapy

 

Migraine

N

HAMD

HADS-A

HI

HF

N

HAMD

HADS-A

HI

HF

Baseline

Yes

136

24.8 ± 4.3**

15.7 ± 3.2**

6.4 ± 3.0**

4.3 ± 2.4**

−

−

−

−

−

Baseline

No

154

22.2 ± 3.8

14.3 ± 3.3

3.2 ± 2.7

2.3 ± 2.2

−

−

−

−

−

Six month

Yes

58

14.2 ± 9.1*

10.0 ± 5.0

3.7 ± 3.0**

2.8 ± 2.5**

60

10.5 ± 6.7**

9.1 ± 4.5**

2.9 ± 2.8**

2.2 ± 2.0***

Six month

No

75

11.0 ± 7.8

9.2 ± 4.7

1.5 ± 1.8

1.5 ± 2.2

61

6.7 ± 5.8

6.1 ± 4.1

1.4 ± 2.0

0.9 ± 1.4

Two year

Yes

34

16.3 ± 7.3**

12.0 ± 4.4**

5.2 ± 3.0**

2.6 ± 2.2**

20

15.7 ± 6.4**

11.9 ± 3.7**

4.8 ± 2.9**

2.6 ± 2.0**

Two year

No

138

8.4 ± 6.6

7.9 ± 4.1

1.5 ± 2.0

1.0 ± 1.5

45

9.6 ± 6.8

8.7 ± 4.3

2.3 ± 2.3

1.6 ± 1.8

Ten year

Yes

38

10.4 ± 5.5**

8.7 ± 4.8*

3.9 ± 3.0**

1.6 ± 1.5**

14

16.0 ± 6.8*

13.4 ± 4.5**

4.5 ± 3.5**

3.2 ± 2.7**

Ten year

No

61

6.4 ± 5.3

6.6 ± 4.1

1.3 ± 2.1

1.0 ± 1.5

24

11.3 ± 6.2

9.6 ± 3.7

1.3 ± 2.0

1.2 ± 1.7

  1. HAMD hamilton depression rating scale, HADS-A anxiety subscale of the Hospital Anxiety and Depression scale, HI headache intensity, HF headache frequency
  2. *P <  0.05; ** Significance after Bonferroni correction with P <  0.0125
  3. aHeadache intensity and frequency were measured using a 0–10 visual analog scale and the pain days of the past week, respectively