Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures

Table 4 Significant FCs between the insular subdivision and the whole brain in males

Insular subdivision	Cluster index	Brain region	Cluster size	MNI coordinate			Peak T-value	FCs increased/ decreased
Insular subdivision	Cluster index	Brain region	Cluster size	X	Y	Z	Peak T-value	FCs increased/ decreased
dld_L	1	Cingulum_Mid/Cingulum_Post/Precuneus_R	73	6	−45	39	4.82	Increased
	2	Cingulum_Mid_R	144	6	9	36	4.76	Increased
	3	Angular_L	71	−39	−72	48	4.96	Increased
	4	Frontal_Mid_L	56	−42	21	39	4.53	Increased

The threshold was set at uncorrected peak level of p < 0.001, FDR correction with threshold of p < 0.05, cluster size ≥50 voxels. T-values of significantly activated peak-voxels referred to MNI coordinates. Brain region labeling was performed using the AAL atlas. T statistics and MNI coordinates were reported for the peak voxel within each cluster. AAL, Automatic Anatomic Labeling; FCs, functional connectivities; L, left; R, right; MNI, Montreal Neurological Institute; dld, dorsal dysgranular insula; Cingulum_Mid, median cingulate and paracingulate gyrus; Cingulum_Post, posterior cingulate gyrus; Frontal_Mid, middle frontal gyrus

ISSN: 1129-2377