Fig. 1

Anti-CGRP l-aptamer NOX-C89 reduces spontaneous neuronal activity. a Normalized activity of spinal trigeminal neurons. After infusion of NOX-C89, spontaneous activity was reduced. In contrast, infusion of the control l-aptamer did not alter neuronal activity. For both groups eight separate experiments were performed, symbols represent activity per 150 s. Note the longer intervals used for thermal testing, the heat and cold protocols are visualized at the bottom. b Twenty minutes after the infusion of NOX-C89 0.5 mg/kg and 5 mg/kg the spontaneous neuronal activity was reduced, both in comparison to baseline activity at the beginning of the experiment (7.5 min period before the first injection, ^#p < 0.05) and to the control group (*p < 0.05). Data are mean ± SEM