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Table 3 Haplotype analysis of the HCRTR2 SNPs between cases and controls

From: Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study

Haplotypes a

Case frequency

Control frequency

p -value

OR (95% CI)

H1-GTGGGG

100.11(0.447)

203.74(0.531)

0.030

0.689 [0.491~0.966]

H2-GTGGAG

26.31(0.117)

29.18(0.076)

0.094

1.602 [0.919~2.794]

H3-AGGAAG

25.17(0.112)

32.34(0.084)

0.270

1.284 [0.728~2.264]

H4-AGGGGG

14.91(0.067)

18.71(0.049)

0.369

1.378 [0.683~2.781]

H5-GGGAAG

8.55(0.038)

17.19(0.045)

0.678

0.838 [0.362~1.936]

H6-GTAGGA

11.05(0.049)

11.89(0.031)

0.262

1.608 [0.696~3.713]

H7-ATGGGG

6.39(0.029)

18.79(0.049)

0.213

0.564 [0.226~1.406]

H8-ATGGAG

8.06(0.036)

12.68(0.033)

0.866

1.081 [0.439~2.657]

  1. aHaplotypes were omitted if the estimated haplotype probability was less than 3%. Order of polymorphisms: rs10498801-rs3122156-rs9357855-rs2653342-rs3800539-rs2653349.Global X2 is 9.928, df = 8, p = 0.277