Table 2 Genotype and allele frequency of the polymorphisms between cases and controls
SNP | CH (n = 112) | Controls (n = 192) | p-value | p corr | Crude OR (95% CI) | Adjusted OR a(95% CI) | |
|---|---|---|---|---|---|---|---|
HCRTR2 | |||||||
rs10498801(G > A) | GG | 53(0.473) | 95(0.495) | 1 | 1 | ||
GA | 46(0.411) | 83(0.432) | 0.979 | 1 | 1.003(0.798-1.261) | 1.014(0.596-1.631) | |
AA | 13(0.116) | 14(0.073) | 0.224 | 0.672 | 1.664(0.728-3.803) | 1.634(0.863-4.125) | |
HWE p-value | 0.536 | 0.473 | |||||
Allele | G | 152(0.679) | 273(0.711) | 1 | – | ||
A | 72(0.321) | 111(0.289) | 0.599 | 1.110(0.771-1.568) | – | ||
rs2653342(A > G) | GG | 100(0.893) | 175(0.911) | 1 | 1 | ||
GA | 11(0.098) | 17(0.089) | 0.760 | 1 | 1.132(0.510-2.513) | 1.141(0.519-2.404) | |
AA | 1(0.009) | 0(0.000) | 0.281 | 0.843 | 3.485(0.312-38.91) | – | |
HWE p-value | 0.281 | 0.521 | |||||
Allele | G | 211(0.942) | 367(0.956) | 1 | – | ||
A | 13(0.058) | 17(0.044) | 0.454 | 1.330(0.634-2.793) | – | ||
rs2653349(G > A) | GG | 98(0.875) | 176(0.917) | 1 | 1 | ||
GA | 13(0.116) | 16(0.083) | 0.336 | 1 | 1.459(0.674-3.159) | 1.536(0.709-3.331) | |
AA | 1(0.009) | 0(0.000) | 0.268 | 0.804 | 0.989(0.969-1.010) | – | |
HWE p-value | 0.452 | 0.546 | |||||
Allele | G | 209(0.933) | 368(0.958) | 1 | – | ||
A | 15(0.067) | 16(0.042) | 0.171 | 1.651(0.800-3.407) | – | ||
rs3122156(T > G) | TT | 56(0.500) | 106(0.552) | 1 | 1 | ||
GT | 47(0.420) | 74(0.385) | 0.460 | 1 | 1.202(0.738-1.959) | 1.127(0.427-2.974) | |
GG | 9(0.080) | 12(0.063) | 0.455 | 1 | 1.420(0.564-3.573) | 1.314(0.507-3.410) | |
HWE p-value | 0.843 | 0.847 | |||||
Allele | G | 159(0.710) | 286(0.745) | 1 | – | ||
T | 65(0.290) | 98(0.255) | 0.348 | 1.193(0.825-1.725) | – | ||
rs3800539(G > A) | GG | 48(0.429) | 106(0.552) | 1 | 1 | ||
GA | 54(0.482) | 71(0.370) | 0.038 | 0.114 | 1.680(1.027-2.746) | 1.483(0.564-3.387) | |
AA | 10(0.089) | 15(0.078) | 0.382 | 1 | 1.472(0.617-3.513) | 0.835(0.339-2.057) | |
HWE p-value | 0.342 | 0.522 | |||||
Allele | G | 150(0.670) | 283(0.737) | 1 | – | ||
A | 74(0.330) | 101(0.263) | 0.707 | 1.382(0.965-1.980) | – | ||
rs9357855(G > A) | GG | 65(0.580) | 124(0.646) | 1 | 1 | ||
GA | 41(0.366) | 61(0.318) | 0.326 | 0.978 | 1.282(0.780-2.107) | 1.423(0.444-4.565) | |
AA | 6(0.054) | 7(0.036) | 0.390 | 1 | 1.635(0.528-5.067) | 1.694(0.546-5.257) | |
HWE p-value | 0.887 | 0.881 | |||||
Allele | G | 171(0.763) | 309(0.805) | 1 | – | ||
A | 53(0.237) | 75(0.195) | 0.228 | 1.277(0.857-1.902) | – | ||
ADH4 | |||||||
rs1800759(G > T) | GG | 77(0.688) | 130(0.677) | 1 | 1 | ||
GT | 33(0.295) | 54(0.281) | 0.906 | 1 | 1.032(0.615-1.730) | 1.132(0.524-2.441) | |
TT | 2(0.017) | 8(0.042) | 0.270 | 0.810 | 0.422(0.087-2.039) | 0.464(0.096-2.251) | |
HWE p-value | 0.469 | 0.432 | |||||
Allele | G | 187(0.835) | 314(0.818) | 1 | – | ||
T | 37(0.165) | 70(0.182) | 0.593 | 0.888(0.573-1.375) | – | ||
CLOCK | |||||||
rs1801260(T > C) | AA | 92(0.821) | 167(0.870) | 1 | 1 | ||
AG | 19(0.170) | 23(0.120) | 0.226 | 0.678 | 1.500(0.776-2.898) | 1.471(0.766-2.823) | |
GG | 1(0.009) | 2(0.010) | 0.937 | 1 | 0.908(0.081-10.145) | 1.151(0.533-3.487) | |
HWE p-value | 0.986 | 0.245 | |||||
Allele | A | 203(0.906) | 357(0.930) | 1 | – | ||
G | 21(0.094) | 27(0.070) | 0.301 | 1.368(0.754-2.482) | – | ||