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Table 5 Studies of SPG block for migraine

From: Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review

Migraine
Author Year Medical problems Approach Imaging Medication Number of cases Study design Outcome
Amster et al. [28] 1948 Migraine Cotton tipped applicator, transnasal approach None Nupercaine, pontocaine, monocaine 4 Case series Relief of pain and spasm in 90% of cases
Maizels et al. [56] 1999 Migraine with aura Self-administered intranasal 4% lidocaine None 4% lidocaine 1 Case report Most headaches were successfully aborted for 15 months
Yarnitsky et al. [57] 2003 Migraine Cotton tip applicator None 2% lidocaine 32 Case series Significant reduction in pain score during migraine
Cady et al. [15] 2015 Chronic migraine Tx360 None 0.5% bupivacaine 38 Double blind, placebo control Significantly decreased headache at 24 h
Cady et al. [16] 2015 Chronic migraine Tx360 None 0.5% bupivacaine 38 Double blind, placebo control No statistical difference at 1 month and 6 months between treatment and control groups.