Fig. 9

Middle meningeal artery (MMA) response to 20 min i.v. infusion of CGRP (0.25 μg kg⁻¹ min⁻¹), PACAP1–38 (0.4 μg kg⁻¹ min⁻¹), PACAP1–27 (0.4 μg kg⁻¹ min⁻¹) and PACAP6–38 (0.4 μg kg⁻¹ min⁻¹). The darker color represents experiments performed on control rats while experiments represented with the lighter color are performed in mast cell depleted (MCD) rats. Mean values ± SEM are given as percentage increase in MMA diameter from the pre-stimulation baseline. Statistical analysis by ANOVA (Kruskal-Wallis test) followed by Dunn’s comparison test to compare differences from baseline values (0) ***p < 0.001; **p < 0.01; *p < 0.5. ## p < 0.01; # p < 0.05 compared to the corresponding time point in MCD rats [59]