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Table 1 (abstract P218). Descriptive summary of cannabinoid pharmacokinetic parameters

From: 11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches

Parameters (mean ± SD)

Cannabis decoction (200 ml)

Cannabis oil (1 ml)

p-value

Δ9-THC

 Tlag, hours

0.57 ± 0.19

0.71 ± 0.27

0.356

 Tmax, hours

1.07 ± 0.35

1.29 ± 0.39

0.200

 Cmax, ng/ml

1.58 ± 0.72

3.76 ± 1.15

< 0.01

 AUC0-24, ng/ml · min

3.63 ± 1.84

8.39 ± 2.83

0.011

 t1/2, hours

1.68 ± 1.55

1.65 ± 0.75

0.964

11-OH-THC

 Tlag, hours

0.86 ± 0.63

1.21 ± 0.49

0.283

 Tmax, hours

1.00 ± 0.71

1.43 ± 0.45

0.143

 Cmax, ng/ml

0.49 ± 0.41

1.19 ± 0.85

0.054

 AUC0-24, ng/ml · min

0.85 ± 0.84

1.98 ± 1.41

0.044

 t1/2, hours

0.70 ± 0.51

1.90 ± 2.70

0.33

THC-COOH

 Tlag, hours

1.07 ± 0.35

1.21 ± 0.27

0.356

 Tmax, hours

2.00 ± 0.76

2.14 ± 1.03

0.752

 Cmax, ng/ml

4.74 ± 1.70

8.13 ± 4.74

0.037

 AUC0-24, ng/ml · min

22.61 ± 15.05

44.25 ± 42.26

0.203

 t1/2, hours

3.80 ± 3.99

6.29 ± 6.38

0.452

THC-glucuronate

 Tlag, hours

1.36 ± 0.24

1.21 ± 0.27

0.356

 Tmax, hours

4.43 ± 1.13

3.14 ± 0.69

0.035

 Cmax, ng/ml

30.47 ± 8.23

31.92 ± 9.34

0.471

 AUC0-24, ng/ml · min

453.69 ± 86.48

556.66 ± 258.97

0.208

 t1/2, hours

20.75 ± 5.69

20.05 ± 7.23

0.843

CBD

 Tlag, hours

0.50 ± 0.00

0.79 ± 0.39

0.103

 Tmax, hours

0.57 ± 0.19

0.93 ± 0.35

0.047

 Cmax, ng/ml

5.32 ± 2.80

3.49 ± 2.81

0.256

 AUC0-24, ng/ml · min

5.16 ± 2.46

3.35 ± 2.09

0.157

 t1/2, hours

0.53 ± 0.19

0.52 ± 0.31

0.923

  1. Data were analysed with paired T-test (2 dependent means)
  2. SD standard deviation