Treatment | Doses (μg/kg) | Diastolic blood pressure (DBP) (mm Hg) | Heart rate (HR) (beats/min) | ||
---|---|---|---|---|---|
Before | After | Before | After | ||
20% (v/v) propylen glycol | 1a | 55 ± 11 | 55 ± 12 | 200 ± 1 | 200 ± 1 |
Dihydroergotamine | 3100 | b | b | 253 ± 45 | 285 ± 38 |
Salinec | 1a | 44 ± 5 | 44 ± 5 | 232 ± 11 | 232 ± 11 |
Prazosinc | 30 | 42 ± 3 | 42 ± 3 | 234 ± 8 | 232 ± 9 |
Rauwolscinec | 300 | 48 ± 3 | 51 ± 3 | 235 ± 11 | 244 ± 8 |
Prazosin+rauwolscinec | 30 + 300 | 38 ± 3 | 41 ± 5 | 252 ± 10 | 234 ± 8 |
1% (w/v) ascorbic acid | 1a | 57 ± 3 | 60 ± 3 | 220 ± 12 | 220 ± 12 |
Ritanserin | 100 | 70 ± 8 | 70 ± 8 | 193 ± 13 | 193 ± 13 |
Saline | 1a | 68 ± 10 | 65 ± 9 | 201 ± 26 | 203 ± 27 |
Prazosin | 10 30 | 74 ± 11 61 ± 5 | 75 ± 10 61 ± 6 | 243 ± 8 183 ± 31 | 245 ± 17 183 ± 31 |
Rauwolscine | 100 300 | 63 ± 5 51 ± 3 | 60 ± 5 47 ± 4 | 213 ± 7 238 ± 13 | 214 ± 8 240 ± 14 |
Prazosin + rauwolscine | 30 + 300 | 51 ± 4 | 45 ± 5 | 218 ± 9 | 224 ± 14 |
5-methylurapidil | 30 100 | 50 ± 7 54 ± 9 | 51 ± 6 52 ± 8 | 228 ± 15 232 ± 14 | 224 ± 12 236 ± 16 |
L-765,314 | 30 100 | 68 ± 8 64 ± 8 | 65 ± 8 63 ± 10 | 238 ± 20 226 ± 11 | 240 ± 16 226 ± 11 |
BMY 7378 | 30 100 | 68 ± 9 63 ± 3 | 66 ± 10 60 ± 3 | 240 ± 12 256 ± 12 | 238 ± 12 251 ± 13 |
BRL44408 | 100 300 | 65 ± 4 52 ± 8 | 65 ± 4 53 ± 9 | 232 ± 22 228 ± 13 | 228 ± 20 225 ± 15 |
Imiloxan | 300 1000 3000 | 70 ± 10 69 ± 10 68 ± 6 | 69 ± 9 66 ± 11 66 ± 7 | 246 ± 9 247 ± 9 268 ± 16 | 248 ± 9 252 ± 7 271 ± 16 |
JP-1302 | 300 1000 | 58 ± 3 63 ± 7 | 58 ± 3 62 ± 10 | 247 ± 14 212 ± 10 | 278 ± 13 212 ± 10 |