Fig. 5

Increases in diastolic blood pressure by i.v. dihydroergotamine (1–3100 μg/kg) after i.v. treatment with: (a) 5-methylurapidil; (b) L-765,314; or (c) BMY 7378 in animals pretreated (i.v.) with 100 μg/kg ritanserin. Empty symbols depict either: (i) the responses to DHE in the group pretreated with 100 μg/kg ritanserin followed by 1 ml/kg saline (◇, which depicts the same data as those shown in Fig. 3, but it is illustrated here as the control for comparative purposes); or (ii) non-significant responses (△,▽) versus control (◇). Solid symbols (▲,▼) represent significantly different responses (P < 0.05) versus control (◇). ^δ P < 0.05 versus 30 μg/kg of: 5-methylurapidil (a), L-765,314 (b) or BMY 7378 (c). Data are shown as means ± SEM. Δ Diastolic blood pressure stands for “increases in diastolic blood pressure”