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Table 2 Demographic characteristics and prevalence of comorbid conditions in patients with definite and unconfirmed CH and controls

From: The comorbidity burden of patients with cluster headache: a population-based study

 

Definite

n = 75

Control

n = 152

Unconfirmed

n = 22

 

Mean age in years (range)

43.4

(20–74)

 

44

(20–74)

Proportion of males

80%

80%

45%

Comorbidity

%

%

%

p value definite v controls

Pearson chi-square

Attention deficit disorder

4

2

0

0.4

Anxiety

7

8

18

0.7

Arthritis/Rheumatologic condition

15

11

14

0.4

Asthma

7

7

0

1

Back pain/Spine condition

17

14

14

0.56

Celiac disease

1

0

0

0.32

Cerebrovascular disease

1

1

0

1

Cigar smoking

4

1

0

0.17

Cigarette smoking

64

32

31

0.00077***

Congenital disease

0

3

0

0.08

COPD

1

1

0

1

Cardiovascular disease

15

16

36

0.85

Dental/TMJ

4

0

5

0.04*

Depression

17

7

23

0.03*

Deviated septum

7

1

5

0.03*

Diabetes

0

9

5

0.002**

Divorce

13

7

14

0.16

Endocrine

8

3

9

0.12

Alcohol abuse

17

8

5

0.054

Alcohol moderate

1

3

0

0.31

Fibromyalgia

5

1

0

0.1

GERD

8

10

9

0.62

GI procedures

7

8

0

0.79

Glaucoma/Ocular

3

3

5

1

Head trauma

5

1

9

0.1

Hematologic

3

7

14

0.19

Hyperlipidemia

25

25

32

1

Hypertension

15

22

18

0.2

Irritable bowel syndrome

4

1

14

0.17

Infectious

5

4

9

0.73

Malignancy

9

16

14

0.13

Marijuana

8

4

9

0.23

Musculoskeletal/Ortho

7

16

5

0.046*

Nephrolithiasis

7

2

0

0.08

Ob/Gyn

4

5

0

0.73

Obesity

3

7

9

0.19

Other GI

9

24

5

0.004**

Other Headache

5

3

5

0.47

Other Neurologic

4

7

9

0.35

Other Pain, e.g. fibromyalgia

3

5

0

0.47

Other Psychiatric disorder

7

5

14

0.55

Other sleep

3

5

5

0.47

Other Substance abuse

3

4

9

0.7

Peptic ulcer disease

4

1

9

0.17

Renal

1

3

0

0.31

Restless legs

0

0

0

1

Seizure disorder

5

5

5

1

Sinus problems

5

8

9

0.39

Skin conditions

4

19

5

0.0008***

Sleep apnea

9

5

5

0.27

Suicide attempt

0

1

0

0.32

Tendinitis

7

3

5

0.19

Trigeminal neuralgia

0

0

0

1

Urologic

5

10

5

0.18

Vascular malformation

1

0

0

0.32

Violent trauma

0

2

0

0.16

  1. Abbreviations: ADD attention deficit disorder, COPD chronic obstructive pulmonary disease, GI gastrointestinal, Ob/gyn obstetrical or gynecological diagnoses
  2. *significant at <0.05, **significant at <0.01, ***significant at <0.001