Fig. 3
Summary of PACAP, Substance P, TNF-α, IL-6 and IL-1β immunoreactivity in the C1-C2 region of the spinal cord. PACAP immunoreactivity was detected in the dorsal horn and in almost every tract of the spinal cord. Substance P immunoreactvity was limited to the fibers of the spinal trigeminal tract. TNF-α immunopositivity was mainy seen in the small cells surrounding the central canal. IL-6 immunopositivity was shown in the large neurons of the anterior horn and in nerve endings of these cells. IL-1 β immunopositvity was mainy seen in different tracts of the spinal cord, few positive cells, with granular intracytoplasmatic staining were also detected