Fig. 2

Depression and anxiety scale scores. a–d: Depression-associated scores. e–h: Anxiety-associated scores. Facial withdraw threshold. b–e: Depressive behaviours. i: All depression scores together. j: All anxiety scores together. k: Relationship between total anxiety and total depression scores. The results were similar to the primary behavioural data, except for the inner zone time percentage (IT%) (f), which was significantly different, and open-arm entries (OE%) (h), in which the significant difference disappeared. Total depression (i) and anxiety scores (j) were significantly lower in the IS group (*P < 0.05, ***P < 0.001, IS vs. CON) but improved in the IS + AMI group (##P < 0.01, IS vs. IS + AMI). More depression paralleled more anxiety in most of the rats (k). However, a few rats had only anxiety or only depression