Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

Table 3 The decreased functional connectivity of abnormal brain region with altered FCD among NC, EM and MOH

Seed region		Anatomic region	MNI-space			Cluster size	T value
Seed region		Anatomic region	X	Y	Z	Cluster size	T value
MOH vs NC
ParaHippocampal_R	MOH < NC	Frontal_Sup_Medial_R	6	42	39	199	4.47
	MOH < NC	Frontal_Sup_R	27	63	9	140	4.39
EM vs NC
Cingulum_Ant_L
	EM < NC	Temporal_Pole_Sup_L	−27	9	−30	24	4.72
Frontal_Inf_Orb_R
	EM < NC	Hippocampus_R	30	−18	−12	31	4.92
		Calcarine_L	−9	−78	15	45	4.32
		Occipital_Sup_R	27	−69	36	91	4.06
		Lingual_L	−18	−87	−15	43	3.89
MOH vs EM
Caudate_R
	MOH < EM	Frontal_Inf_Tri_L	−33	30	12	715	8.87
		Temporal_Sup_R	45	−24	15	133	6.98
		Temporal_Mid_R	66	−54	−6	337	6.85
		Frontal_Sup_Medial_R	9	27	45	307	6.78
		Fusiform_L	−45	−48	−21	276	6.47
		Angular_R	33	−57	45	232	6.28
		Insula_R	33	24	9	198	6.00
		Rolandic_Oper_R	63	12	12	137	5.99
Insula_L
	MOH < EM	Frontal_Inf_Tri_L	−33	30	12	677	9.48
		Occipital_Inf_L	−48	−66	−15	352	7.38
		Temporal_Sup_R	45	−27	15	110	7.04
		Frontal_Sup_Medial_R	12	27	45	253	6.90
		Temporal_Inf_R	57	−51	−9	275	6.83
		Frontal_Mid_R	45	45	9	132	6.63
		Parietal_Sup_R	36	−60	54	138	6.39
		Occipital_Mid_L	−27	−63	42	103	6.25
		Frontal_Inf_Oper_R	51	9	30	182	6.24

dmPFC dorsal-medial prefrontal cortex, vlPFC ventral-lateral prefrontal cortex, MNI Montreal Neurological Institute, X, Y, Z coordinates of the primary maximum of the cluster

ISSN: 1129-2377