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Table 4 Main results: univariate and multivariate analysis of primary and secondary endpoint*

From: Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

a. Univariate analysis of primary and secondary endpoint

 

Serious secondary headache

Composite endpoint mortality or hospitalization

Predictors

OR

95%CI

p

OR

95%CI

p

 Copeptin (lna)

2.03

1.52–2.70

<0.0001

1.45

1.12.1.88

0.005

 Age > 50

2.83

1.69–4.74

<0.0001

2.77

1.72–4.46

<0.0001

 Male gender

2.12

1.27–3.52

0.004

1.41

0.88–2.27

0.150

 Focal-neurological symptoms

3.50

1.99–6.14

<0.0001

4.23

2.47–7.24

<0.0001

 Thunderclap onset

4.23

2.38–7.52

<0.0001

3.04

1.75–5.29

<0.0001

 Scenario 4*

0.46

0.24–0.87

0.018

0.56

0.32–0.97

0.040

 D-Dimer (lna)

1.50

1.00–2.27

0.052

1.28

0.87–1.89

0.205

 Fibrinogen (lna)

2.95

1.10–7.89

0.031

2.29

0.91–5.80

0.080

 C-reactive protein (lna)

1.06

0.87–1.30

0.544

1.31

1.07–1.60

0.010

 Leukocyte count (lna)

2.04

1.01–4.13

0.046

0.63

0.34–1.16

0.136

b. Multivariate model 1: Copeptin and clinical variables

 

Serious secondary headache

Composite endpoint mortality or hospitalization

Predictors

OR

95%CI

Predictors

OR

95%CI

p

 Copeptin (lna)

1.73

1.26–2.40

0.001

1.23

0.91–1.65

0.173

 Age > 50

2.25

1.28–3.96

0.005

2.34

1.41–3.89

0.001

 Male gender

1.84

1.04–3.26

0.035

   

 Focal-neurological symptoms

2.63

1.40–4.92

0.003

3.41

1.94–6.02

<0.0001

 Thunderclap onset

2.90

1.49–5.65

0.002

2.21

1.18–4.15

0.013

 Scenario 4b

0.73

0.35–1.50

0.388

0.81

0.43–1.51

0.503

c. Multivariate model 2: Copeptin and laboratory variablesa

 

Serious secondary headache**

Composite endpoint mortality or hospitalization***

Predictors

OR

95%CI

p

OR

95%CI

p

Copeptin (ln)

1.80

1.33–2.44

<0.0001

1.39

1.0–1.94

0.050

Fibrinogen (ln)

1.22

0.93–1.61

0.158

   

Leukocyte count (ln)

1.78

0.82–3.83

0.143

   

C-reactive protein (ln)

   

1.27

1.04–1.56

0.021

  1. *n = 75 events for the primary endpoint, n = 94 events for the secondary endpoint
  2. aAll laboratory values were transformed by natural logarithm (ln)
  3. bScenario 4 of Grimaldi et al. [7]: previous headache history presenting with a similar episode
  4. For model 2, we performed a subgroup analysis of **n = 327 and ***n = 279 patients with available values of fibrinogen, leukocyte count, and C-reactive protein
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The Journal of Headache and Pain

ISSN: 1129-2377

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