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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system

Fig. 4

The effect of mild closed head injury (CHI) frequency with or without a day of recovery on trigeminal allodynia thresholds (grams) measured using von Frey filaments. Thresholds for repetitive CHI groups with two or three injuries (RCHI2, RCHI3) and incision controls (control) with 1 day of recovery (1 day) and without a day of recovery (0 days) (a). Trigeminal thresholds for RCHI3 (0 days) without a day of recovery between injuries, **p < 0.01 compared to control. Thresholds for CHI, RCHI2, RCHI3 and controls without a day of recovery (0 days) over one week after injury (b). Trigeminal thresholds for groups receiving single CHI, RCHI2 and RCHI3, ***p < 0.001 compared to control, ##p < 0.01and #p < 0.05 compared to CHI. Dashed line at ≤ 6 g represents allodynia

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The Journal of Headache and Pain

ISSN: 1129-2377

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