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Table 1 Main characteristics of all eligible studies

From: The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis

First author

Year

Country

Ethnicity

Eligible participants (M/F)

Age, mean (SD), years

Genotype method

SNPa

HWE

NOS

Cases

Controls

Cases

Controls

Salih et al.

2016

Turkey

Caucasian

288 (137/151)

288 (133/155)

31.26 (10.28)

31.53 (8.92)

RT-PCR

1,2

yes

6

Heidi et al.

2014

Australia

Caucasian

277

277

-

-

PCR-RFLP

1,2

yes

7

Heidi et al.

2014

Australian

Caucasian

580

580

-

-

PCR-RFLP

1,2

yes

7

Carolina et al.

2010

Portugal

Caucasian

188 (35/153)

287 (70/217)

36.14 (12.84)

36.42 (12.35)

RT-PCR

1,2

yes

7

Martin et al.

2008

German

Caucasian

265 (43/222)

153 (43/110)

43.6 (13)

64.5 (9.4)

RT-PCR

1

yes

7

  1. Abbreviation: M male, F female, SNP single-nucleotide polymorphism, HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, PCR-RELP polymerase chain reaction-restricted fragments length polymorphism, RT-PCR real-time polymerase chain reaction
  2. a1 = rs6265; 2 = rs2049046