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Table 3 Triptan sensations after treatment with 3 and 6 mg SC sumatriptan

From: Randomized, double-blind, crossover study comparing DFN-11 injection (3 mg subcutaneous sumatriptan) with 6 mg subcutaneous sumatriptan for the treatment of rapidly-escalating attacks of episodic migraine

 

3 mg SC sumatriptan

6 mg SC sumatriptan

 

Event frequency

n (%)

Durationa

Min

Severitya,b

(1–3)

Event frequency

n (%)

Durationa

Min

Severitya,b

(1–3)

Paresthesia

5 (15.63)

13.0 (.01)

1.20 (.45)

4 (12.50)

20.0 (.01)

1.0 (0.0)

Neck Pain

4 (12.50)

12.0 (.01)

1.25 (.50)

3 (9.38)

11.0 (.00)

1.0 (0.0)

Flushing

2 (6.25)

25.0 (.01)

1.50 (.71)

2 (6.25)

11.0 (.01)

1.50 (.71)

Muscle Contractions (Neck)c

1 (3.13)

44 (N/A)

1.0 (N/A)

2 (6.25)

47 (N/A)

1.50 (.71)

Chest Pain

0 (0)

—

—

2 (6.25)

374 (.35)

2.0 (1.41)

Disorientation

0 (0)

—

—

1 (3.13)

19 (N/A)

1.0 (N/A)

Dizziness

0 (0)

—

—

1 (3.13)

20 (N/A)

1.0 (N/A)

Myalgia

0 (0)

—

—

1 (3.13)

44 (N/A)

1.0 (N/A)

Tinnitus

0 (0)

—

—

1 (3.13)

41 (N/A)

1.0 (N/A)

Vomiting

0 (0)

—

—

1 (3.13)

41 (N/A)

1.0 (N/A)

Hyperhidrosis

1 (3.13)

38 (N/A)

1.0 (N/A)

0 (0)

—

—

Malaise

1 (3.13)

130 (N/A)

2.0 (N/A)

0 (0)

—

—

Total

14 (44)d

27 (33.12)e

1.29 (.47)f

18 (56)

64 (167.10)

1.28 (.57)

  1. SC subcutaneous
  2. aMean (SD)
  3. bAssessed on a 3-point Likert scale: mild  =  1, moderate  =  2, and severe  =  3
  4. cInvoluntary
  5. d P  =  .60 vs 6 mg
  6. e P  =  .43 vs 6 mg
  7. f P  =   .97 vs 6 mg
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The Journal of Headache and Pain

ISSN: 1129-2377

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