Fig. 1

The default mode network (DMN) functional connectivity in migraineurs without aura and healthy controls and the differences between the groups. a DMN network of each group was obtained by one-sample t test (FDR corrected, p = 0.001). The brain areas of the DMN comprised of the medial prefrontal cortex, anterior and posterior cingulate cortexes, precuneus, angular gyrus and cerebellar areas in the migraine and control groups. b Compared with the control group, the migraineurs without aura showed significantly increased intra-network connectivity in the left posterior cingulate and precuneus. c The mean ICA z-scores were extracted from the significantly altered brain area in each subject. No significant differences in intra-network FC were observed between the female and male migraineurs. d The ICA z-score of the precuneus/PCC was positively correlated with the HIT-6 score (r = 0.46, P < 0.05). HC, healthy control; M, migraineurs without aura