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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats

Fig. 6

Schematic representation of possible mechanisms for the antinociceptive effects of intrathecal (i.t.) transforming growth factor-β1 (TGF-β1) during neuropathic pain. I.t. TGF-β1 may attenuate peripheral nerve injury-induced thermal hyperalgesia (Pathway 1). Upregulation of phosphorylated (phospho)-p38 and phosphorylated extracellular signal-regulated kinase (phospho-ERK) is a mechanism for nerve injury-induced pain (Pathway 2). The antinociceptive effects of i.t. TGF-β1 may occur via suppression of nerve injury-induced upregulation of phospho-p38 and phospho-ERK (Pathway 3)

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The Journal of Headache and Pain

ISSN: 1129-2377

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