Headache: an important factor associated with muscle soreness/pain at the two-year follow-up point among patients with major depressive disorder

Table 2 The intensities of muscle soreness/pain between groups among patients with major depressive disorder at baseline and follow-up^a

Time points	Treatment	Comorbidities at baseline^b		Number	Neck	Shoulder	Back	Upper limbs	Lower limbs
Baseline		Full sample		155	5.0 ± 3.5	5.1 ± 3.6	3.8 ± 3.6	2.6 ± 3.2	2.3 ± 3.0
	No Tx	Migraine	Yes	73	6.4 ± 3.2**	6.8 ± 3.2**	5.1 ± 3.7**	3.5 ± 3.4**	3.3 ± 3.2**
	No Tx	Migraine	No	82	3.7 ± 3.3	3.7 ± 3.3	2.6 ± 3.1	1.7 ± 2.8	1.4 ± 2.4
	No Tx	Anxiety	Yes	70	5.7 ± 3.5*	6.1 ± 3.5**	4.6 ± 3.9**	3.4 ± 3.4**	3.1 ± 3.3**
	No Tx	Anxiety	No	85	4.4 ± 3.5	4.3 ± 3.5	3.1 ± 3.2	1.9 ± 2.9	1.7 ± 2.6
Two years	–	Full sample		131	3.0 ± 3.2	3.3 ± 3.1	2.0 ± 2.8	1.3 ± 2.3	1.5 ± 2.3
	No Tx	Migraine	Yes	43	3.2 ± 3.6	3.9 ± 3.5	2.6 ± 3.3	1.9 ± 3.0*	2.0 ± 2.8*
	No Tx	Migraine	No	58	2.8 ± 3.0	2.8 ± 2.8	1.8 ± 2.6	0.8 ± 1.4	1.1 ± 1.6
	No Tx	Anxiety	Yes	45	3.4 ± 3.5	4.0 ± 3.4*	2.7 ± 3.3	1.9 ± 3.0*	2.0 ± 2.8*
	No Tx	Anxiety	No	56	2.7 ± 3.0	2.7 ± 2.8	1.7 ± 2.5	0.7 ± 1.4	1.0 ± 1.6
	Tx	Migraine	Yes	17	3.7 ± 2.8*	4.3 ± 2.9	2.2 ± 2.4	1.7 ± 2.6	2.1 ± 2.9
	Tx	Migraine	No	13	1.5 ± 3.0	2.0 ± 3.1	1.2 ± 2.5	1.1 ± 1.8	1.2 ± 2.3
	Tx	Anxiety	Yes	16	3.7 ± 3.2	4.0 ± 3.3	1.9 ± 2.7	1.3 ± 2.0	1.9 ± 2.7
	Tx	Anxiety	No	14	1.7 ± 2.6	2.5 ± 3.0	1.7 ± 2.2	1.5 ± 2.7	1.5 ± 2.6

Tx accepted pharmacotherapy in the index follow-up month
^aThe independent t test and the Mann-Whitney U test were used where appropriate
^bAnxiety comorbidities represented patients with at least one of following anxiety disorders: panic disorder, agoraphobia, social phobia, specific phobia, post-traumatic stress disorder, obsessive–compulsive disorder, and generalized anxiety disorder
*P < 0.05; **P < 0.01

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