Table 1 Clinical features of CADASIL and CADASIL-like patients
Clinical manifestations | CADASIL patients (n = 24) | CADASIL-like patients (n = 92) | P |
|---|---|---|---|
Age, years | 55.08 ± 2.40 | 58.89 ± 0.86 | 0.072 |
Age at onset | 52.67 ± 2.64 | 55.48 ± 0.88 | 0.200 |
Duration from first onset to diagnosis | 2.00 ± 0.55 | 1.07 ± 0.25 | 0.104 |
History of vascular risk factors | |||
Elevated blood pressure, % | 33.33 | 76.09 | 0.000 |
Diabettes Mellitus, % | 25.00 | 23.91 | 0.912 |
Cigarette smoking, % | 58.33 | 47.83 | 0.359 |
Alcohol intake, % | 25.00 | 23.91 | 0.912 |
Onset-manifestation | |||
Migraine, % | 33.33 | 23.91 | 0.348 |
acute cerebral events, % | 66.67 | 58.70 | 0.477 |
psychiatric disturbances, % | 25.00 | 13.04 | 0.261 |
cognitive impairment,% | 41.67 | 41.30 | 0.974 |
Recurrent stroke, % | 58.33 | 19.57 | 0.028 |
Presence of family history of migraine in at least 1 generation, % | 25.00 | 4.35 | 0.005 |
Presence of family history of migrane in at least 2 generation, % | 16.66 | 3.26 | 0.048 |
Presence of family history of acute cerebral events in at least 1 generation, % | 41.66 | 8.70 | 0.000 |
Presence of family history of acute cerebral events in at least 2 generation, % | 33.33 | 5.43 | 0.000 |
Presence of family history of psychiatric disturbance/cognitive impairment at least 1 generation, % | 8.30 | n.r | - |
Presence of family history of psychiatric disturbance/cognitive impairment in at least 2 generation, % | n.r | n.r | - |
CADASIL scale | 16.2 ± 3.1 (10–22) | 14.7 ± 2.5 (8–22) | 0.047 |