Table 3 Clinical characteristics of 149 genotyped CH patients, divided between the three PER3 genotypes 4/4, 4/5 and 5/5

Gender (M/F)

50/17

50/15

9/8

Age at inclusion (years)

52.8, SD ± 14.5

55.6, SD ± 13.5

53.9, SD ± 14.5

Comorbid migraine without aura (N)

1 (1.5 %)

0

3 (17.6 %)

Comorbid migraine with aura (N)

5 (7.5 %)

5 (7.7 %)

1 (5.9 %)

Comorbid tension type headache (N)

1 (1.5 %)

1 (1.5 %)

0

Age at onset (years)

28.9, SD ± 13.1

31.0, SD ± 14.5

31.1, SD ± 13.9

Headache intensity: strong (N)

9 (13.4 %)

4 (6.2 %)

1 (11.8 %)

Headache intensity: extra strong (N)

37 (55.2 %)

39 (60 %)

10 (58.8 %)

Attack duration (minutes)

13.9, SD ± 8.5

13.9, SD ± 9.1

19.0, SD ±11.0

Number of attacks per month

5.7, SD ± 8.2

4.0, SD ± 7.6

4.7, SD ± 11.2

Number of attacks per day

3.3, SD ± 2.2

3.6, SD ± 3.2

3.0, SD ± 2.1

Total number of headache days in the last 3 months

12.3, SD ± 12.1

12.3, SD ± 11.0

17.1, SD ± 16.6

Total number of patients

N = 67

N = 65

N = 17