Fig. 4
From: Nigrostriatal dopaminergic depletion increases static orofacial allodynia
Expression of pERK1/2 in saline-CCI-IoN (a) and 6-OHDA-CCI-IoN animals (b-c). pERK1/2 positive cells were observed within superficial laminae of the MDH in both groups. At high magnification the pERK1/2 positive cells were observed mostly in laminae IIo and I as delimited (yellow dots) in the figure (c). Cell count (d) of pERK1/2 positive cells showed a significant increase (P < 0.01, **) in 6-OHDA vs saline injected animals (n = 5 each group) in the ipsilateral MDH and a non-significant increase in the contralateral side. A significant increase in the number of pERK1/2 positive cells was observed in the ipsilateral side of 6-OHDA injected animals compared to the contralateral side. Scale bar represents 100 μm in A-B and 40 μm in C