Fig. 2

Effects of intraperitoneal (ip) (a, b) and intracisternal (ic) (c, d) administration of bromocriptine, SKF81297 and vehicle on nocifensive behaviors (SMA) in the ipsilateral side of CCI-IoN + saline (a & c) and CCI-IoN + 6-OHDA (B&D). Ip administration (a) of 1 mg/Kg of bromocriptine induces a significant antinociceptive effect in 6-OHDA-lesioned animal (n = 8) when compared to the vehicle group n = 8). This antinociceptive effect occurred 20 min after bromocriptine injection and lasted for up to 6 h. When administered ic (b), bromocriptine (1 μg/Kg, n = 5) decreases significantly the SMA score in comparison to the vehicle group (n = 5). The effect of bromocriptine was observed 20 min after injection and this effect lasted for about 15 min. No significant difference in SMA scores was observed when bromocriptine was injected intracisternally 90 min after the ip administration of sulpiride (c). Error bars = standard deviation. *P < 0.05; **P < 0.01; ***p < 0.001. *: comparison between bromo 1 mg/kg (IP) and vehicle. #: comparison between bromo 0.1 mg/kg (IP) and vehicle